Statistika DiRROS

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Ključne besede: šport, napor, mišice, aktivacija mišic, utrujenost
Objavljeno: 20.12.2021; Ogledov: 1978; Prenosov: 3443
Celotno besedilo (949,44 KB)
Prenosov v mesecu: 139

Opis: We investigated the microstructural evolution of W(111) single crystals under high-energy self-ion irradiation at 290 K and 800 K, using complementary characterization techniques, including Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Rutherford backscattering spectrometry in channelling regime (RBS-C), Positron annihilation spectroscopy (PAS), and Nuclear reaction analysis (NRA). Irradiation with MeV W ions allowed for controlled defect formation, with dose and temperature significantly affecting defect type and distribution. At 290 K, interstitial defects evolved from dislocation loops at low doses (0.02 dpa) to dislocation networks at higher doses (0.2 dpa). In contrast, at 800 K, lower dislocation densities were observed, with nm-sized dots and isolated lines forming at 0.02 dpa and developing into longer dislocation lines (~30 nm) at 0.2 dpa. RBS-C spectra support these findings, showing a trend of increasing dislocation density with dose but decreasing with temperature. PAS analyses revealed mono-vacancies and small vacancy clusters (V2–V4) at 290 K, coalescing into larger clusters (V25–V50) at 800 K. NRA measurements indicated greater deuterium retention at 290 K than at 800 K, consistent with lower vacancy mobility at the lower temperature. Combined TEM, RBS-C, PAS, and NRA observations highlight increased vacancy mobility and defect recombination with temperature, forming larger vacancy clusters at 800 K. This comprehensive study provides quantitative insights into defect formation and evolution in W single crystals, presenting a comparative analysis of defect distributions across multiple techniques and revealing temperature-dependent mechanisms of microstructural change.
Ključne besede: heavy-ion irradiation, structural defects
Objavljeno: 11.12.2025; Ogledov: 128; Prenosov: 155
Celotno besedilo (9,96 MB)
Prenosov v mesecu: 131

Opis: V članku obravnavamo ekologijo, potencialno invazivnost, pomlajevanje, razširjenost in lastnosti rdečega hrasta (Quercus rubra L.) v Sloveniji. V čistem sestoju rdečega hrasta v Panovcu smo s pomočjo transektov (3 ploskve velikosti 4 × 4 m na transekt) v smeri proti sosednjim pretežno gradnovim sestojem analizirali drevesno sestavo in zastiranje mladja. Ugotovili smo, da se rdeči hrast v pasu do 50 m od matičnega sestoja dobro pomlajuje s povprečnimi gostotami okoli 40.000 osebkov na hektar. Zastiranje mladja rdečega hrasta je bilo na robu matičnega sestoja 79 % in se je v oddaljenosti 50 m zmanjšalo na 21 %, medtem ko je delež zastrtosti z mladjem gradna povečal s 4 % na robu sestoja na 39 % 50 m stran. Širjenje rdečega hrasta zunaj matičnih sestojev je razmeroma omejeno in ga je mogoče nadzorovati s pomočjo rednih gozdnogojitvenih ukrepov. Cilj na takih območjih so mešani sestoji, ki vključujejo rdeči hrast, ki hitro raste, je odporen na posledice podnebnih sprememb in ga je mogoče vzgojiti za pridelavo kakovostnega lesa.
Ključne besede: hrast, nega gozda, pomlajevanje, invazivni potencial, tujerodne drevesne vrste
Objavljeno: 19.12.2024; Ogledov: 2366; Prenosov: 846
Celotno besedilo (3,43 MB)
Prenosov v mesecu: 113

Opis: Mixed forests of European beech (Fagus sylvatica L.) and silver fir (Abies alba Mill.) play a vital ecological role in Central and South-Eastern Europe. This study investigates the diversity and composition of soil bacterial communities in these forests, focusing on rhizosphere and bulk soils under varying canopy structures. Soil samples were collected from eight sites along the Carpathian Mountains, including managed forests and the remnants of old growth. Metabarcoding of bacterial communities revealed that alpha diversity (species richness, Shannon index, and evenness) was significantly affected by sampling location but not by forest canopy structure or soil type (rhizosphere and bulk soil). The lowest bacterial diversity was found in the old-growth forest of the Beskidy region, while the highest was recorded in managed forest in Vrancea. Beta diversity analyses showed minimal variation between rhizosphere and bulk soil bacterial communities, with geographic distance being the strongest predictor of community composition. Actinobacteriota and Proteobacteria were the dominant phyla across all sites, with higher relative abundance of Actinobacteriota in all rhizosphere samples compared to bulk soil. Complex combinations of various environmental conditions at each sampling location, including soil parameters (mainly pH and C:N ratio), the age of forest gaps, the type and intensity of disturbances, and species composition of above-ground vegetation, can strongly affect soil bacterial communities. A closer examination of additional environmental variables would be necessary to better explain the observed differences in the diversity and composition of bacterial communities.
Ključne besede: forest gaps, forest management, soil microbiome, soil, rhizosphere, Carpathians, temperate forest
Objavljeno: 30.12.2024; Ogledov: 2007; Prenosov: 853
Celotno besedilo (1,29 MB)
Prenosov v mesecu: 109

Opis: Gene therapy has transitioned from a long-awaited promise to a clinical reality, offering transformative treatments for rare congenital diseases and certain cancers, which have a significant impact on patients’ lives. Current approaches focus on gene replacement therapy, either in vivo or ex vivo, mostly utilizing viral vectors to deliver therapeutic genes into target cells. However, refining these techniques is essential to overcome challenges and complications associated with gene therapy to ensure long-term safety and efficacy. Slovenia has witnessed significant advancements in this field since 2018, marked by successful gene therapy trials and treatments for various rare diseases. Significant strides have been made in the field of gene therapy in Slovenia, treating patients with spinal muscular atrophy and rare metabolic disorders, including the pioneering work on CTNNB1 syndrome. Additionally, immune gene therapy, exemplified by IL-12 adjuvant therapy for cancer, has been a focus of research in Slovenia. Through patient-centred initiatives and international collaborations, researchers in Slovenia are advancing preclinical research and clinical trials, paving the way for accessible gene therapies. Establishing clinical infrastructure and genomic diagnostics for rare diseases is crucial for gene therapy implementation. Efforts in this regard in Slovenia, including the establishment of a Centre for Rare Diseases, Centre for the Technologies of Gene and Cell Therapy, and rapid genomic diagnostics, demonstrate a commitment to comprehensive patient care. Despite the promises of gene therapy, challenges remain, including cost, distribution, efficacy, and long-term safety. Collaborative efforts are essential to address these challenges and ensure equitable access to innovative therapies for patients with rare diseases.
Ključne besede: gene therapy, rare genetic diseases, Slovenia, CAR-T cells, cancer, immune gene therapy
Objavljeno: 04.12.2025; Ogledov: 151; Prenosov: 122
Celotno besedilo (2,18 MB)
Prenosov v mesecu: 105