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Naslov:Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Avtorji:ID Soklič, Tanja (Avtor)
ID Rijavec, Matija, Klinika Golnik, Biotehniška fakulteta UL (Avtor)
ID Šilar, Mira, Klinika Golnik (Avtor)
ID Koren, Ana, Klinika Golnik (Avtor)
ID Kern, Izidor, Klinika Golnik (Avtor)
ID Hočevar-Boltežar, Irena (Avtor)
ID Korošec, Peter, Klinika Golnik (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (698,54 KB)
MD5: D70A5366437474F51F17AE72616F3CCD
 
URL URL - Izvorni URL, za dostop obiščite https://www.degruyter.com/downloadpdf/j/raon.ahead-of-print/raon-2019-0029/raon-2019-0029.pdf
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Background. Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery. We aimed to evaluate the master transcription factors gene expression levels of T cell subtypes in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP) that could represent new, up-stream targets for topical DNAzyme treatment. Patients and methods. Twenty-two newly diagnosed CRS patients (14 CRSwNP and 8 CRSsNP) were prospectively biopsied and examined histopathologically. Gene expression levels of T-box transcription factor (T-bet, TBX21), GATA binding protein 3 (GATA3), Retinoic acid-related orphan receptor C (RORC) and Forkhead box P3 (FOXP3) were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). Results. Eosinophilic CRSwNP was characterized by higher level of GATA3 gene expression compared to noneosinophilic CRSwNP, whereas there was no difference in T-bet, RORC and FOXP3 between eosinophilic and noneosinophilic CRSwNP. In CRSsNP, we found simultaneous upregulation of T-bet, GATA3 and RORC gene expression levels in comparison to CRSwNP; meanwhile, there was no difference in FOXP3 gene expression between CRSwNP and CRSsNP. Conclusions. In eosinophilic CRSwNP, we confirmed the type 2 inflammation by elevated GATA3 gene expression level. In CRSsNP, we unexpectedly found simultaneous upregulation of T-bet and GATA3 that is currently unexplained; however, it might originate from activated CD8+ cells, abundant in nasal mucosa of CRSsNP patients. The elevated RORC in CRSsNP could be part of homeostatic nasal immune response that might be better preserved in CRSsNP patients compared to CRSwNP patients. Further data on transcription factors expression rates in CRS phenotypes are needed.
Ključne besede:sinusitis, nasal polyps, Th1 cells, Th2 cells, Th17 cells, transcription factors, chronic rhinosinusitis
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Kraj izida:Slovenija
Založnik:Association of Radiology and Oncology
Leto izida:2019
Št. strani:str. 323-330
Številčenje:Vol. 53, iss. 3
PID:20.500.12556/DiRROS-12541 Novo okno
UDK:616.21
ISSN pri članku:1581-3207
DOI:10.2478/raon-2019-0029 Novo okno
COBISS.SI-ID:2048522353 Novo okno
Avtorske pravice:© 2019 Tanja Kosak Soklic, Matija Rijavec, Mira Silar, Ana Koren, Izidor Kern, Irena Hocevar- Boltezar, Peter Korosec
Opomba:Soavtorji: Matija Rijavec, Mira Silar, Ana Koren, Izidor Kern, Irena Hocevar-Boltezar, Peter Korosec; Nasl. z nasl. zaslona; Opis vira z dne 26. 7. 2019;
Datum objave v DiRROS:09.10.2020
Število ogledov:1861
Število prenosov:1002
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del revije

Naslov:Radiology and oncology
Založnik:Association of Radiology and Oncology
ISSN:1581-3207
COBISS.SI-ID:784507 Novo okno

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Licenca:CC BY-NC-ND 3.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 3.0 Nedoločena
Povezava:https://creativecommons.org/licenses/by-nc-nd/3.0/deed.sl
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Začetek licenciranja:17.07.2019

Sekundarni jezik

Jezik:Ni določen
Ključne besede:sinizutis, nosni polipi, celice Th1, celice Th2, celice Th17, transkripcijski faktorji, kronični rinosinuzitis


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