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Naslov:Cabbage and fermented vegetables : from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
Avtorji:Bousquet, Jean (Avtor)
Antò i Boquè, Josep M. (Avtor)
Czarlewski, Wienczyslawa (Avtor)
Haahtela, Tari (Avtor)
Fonseca, Susana C. (Avtor)
Laccarino, Guido (Avtor)
Blain, Hubert (Avtor)
Vidal, Alain (Avtor)
Sheikh, Aziz (Avtor)
Akdis, Cezmi A. (Avtor)
Zuberbier, Torsten (Avtor)
Kreft, Samo (Avtor)
Jenko, Klemen (Avtor)
Jošt, Maja (Avtor)
Kopač, Peter (Avtor)
Košnik, Mitja (Avtor)
Kramer Vrščaj, Karmen (Avtor)
Madjar, Bojan (Avtor)
Plavec, Davor (Avtor)
Soklič, Tanja (Avtor)
Urbančič, Jure (Avtor)
Zidarn, Mihaela (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage were associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin converting enzyme 2 (ACE2). As a result of SARS-Cov-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistanceas well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are given: Kimchi in Korea, westernized foods and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects helpful in mitigating COVID-19 severity.
Ključne besede:COVID-19, diet, sulforaphane, Lactobacillus, Angiotensin converting enzyme 2, kimchi, cabbage, fermented vegetable
Leto izida:2020
Založnik:John Wiley & Sons
Izvor:Velika Britanija
UDK:578:635.34:663.15:
ISSN pri članku:1398-9995
OceCobissID:515009305 Povezava se odpre v novem oknu
COBISS_ID:26203907 Povezava se odpre v novem oknu
DOI:10.1111/all.14549 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Opis vira z dne 26. 8. 2020;
Število ogledov:333
Število prenosov:70
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://onlinelibrary.wiley.com/doi/10.1111/all.14549
 
Nadgradivo:Allergy
Blackwell
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:2020 EAACI and John Wiley and Sons
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