20.500.12556/DiRROS-12522 Cabbage and fermented vegetables : from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19 Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage were associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin converting enzyme 2 (ACE2). As a result of SARS-Cov-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistanceas well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are given: Kimchi in Korea, westernized foods and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects helpful in mitigating COVID-19 severity. COVID-19 diet sulforaphane Lactobacillus Angiotensin converting enzyme 2 kimchi cabbage fermented vegetable koronavirus fermentirana zelenjava kimči COVID-19 true false true John Wiley & Sons Angleški jezik Ni določen 2020 EAACI and John Wiley and Sons Neznano 2020-10-07 09:23:52 2020-10-07 09:23:53 2022-08-18 03:37:53 0000-00-00 00:00:00 2020 0 Velika Britanija 0 Nasl. z nasl. zaslona; Opis vira z dne 26. 8. 2020; str. [1-38] iss. Vol. 2020 0000-00-00 PostprintKoncna VTisku NiDoloceno 0000-00-00 0000-00-00 0000-00-00 578:635.34:663.15: 1398-9995 10.1111/all.14549 26203907 515009305 https://onlinelibrary.wiley.com/doi/10.1111/all.14549 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=15212 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0