| Naslov: | Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity : a systematic review and meta-analysis |
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| Avtorji: | ID Tratenšek, Armando (Avtor)
ID Locatelli, Igor (Avtor)
ID Grabnar, Iztok (Avtor)
ID Drobne, David (Avtor)
ID Vovk, Tomaž (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (5,86 MB)
MD5: B563DA0646E76487A1B2486C1F6D0A46
 URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S2213231724003586
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid Embase, and Web of Science databases, identifying 54 studies for inclusion. Comparisons included: (I) active IBD versus healthy controls; (II) inactive IBD versus healthy controls; (III) active CD versus inactive CD; and (IV) active UC versus inactive UC. Our analysis revealed a significant accumulation of biomarkers of oxidative damage to biomacromolecules, coupled with reductions in various antioxidants, in both patients with active and inactive IBD compared to healthy controls. Additionally, we identified biomarkers that differentiate between active and inactive CD, including malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity. Similarly, levels of Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC. Vitamins and carotenoids likewise emerged as potential disease activity biomarkers for CD and UC, but their intake should be monitored to obtain meaningful results. These findings emphasize the involvement of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers as a minimally invasive and additional tool for monitoring the activity of IBD. |
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| Ključne besede: | inflammatory bowel disease, ulcerative colitis, Crohn's disease, oxidative stress, biomarker, meta-analysis |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | 14 str. |
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| Številčenje: | Vol. 77, article no. 103380 |
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| PID: | 20.500.12556/DiRROS-30737  |
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| UDK: | 612.015:616.1/.4-036.1 |
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| ISSN pri članku: | 2213-2317 |
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| DOI: | 10.1016/j.redox.2024.103380 |
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| COBISS.SI-ID: | 209789443 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 2. 10. 2024;
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| Datum objave v DiRROS: | 01.07.2026 |
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| Število ogledov: | 160 |
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| Število prenosov: | 141 |
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| Metapodatki: |    |
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