20.500.12556/DiRROS-30737 Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity a systematic review and meta-analysis Oxidative stress is believed to play an important role in the pathogenesis of inflammatory bowel disease (IBD), specifically Crohn's disease (CD) and ulcerative colitis (UC). This meta-analysis aimed to identify and quantify the oxidative stress-related biomarkers in IBD and their associations with disease activity. We systematically searched Ovid MEDLINE, Ovid Embase, and Web of Science databases, identifying 54 studies for inclusion. Comparisons included: (I) active IBD versus healthy controls; (II) inactive IBD versus healthy controls; (III) active CD versus inactive CD; and (IV) active UC versus inactive UC. Our analysis revealed a significant accumulation of biomarkers of oxidative damage to biomacromolecules, coupled with reductions in various antioxidants, in both patients with active and inactive IBD compared to healthy controls. Additionally, we identified biomarkers that differentiate between active and inactive CD, including malondialdehyde, Paraoxonase 1, catalase, albumin, transferrin, and total antioxidant capacity. Similarly, levels of Paraoxonase 1, erythrocyte glutathione peroxidase, catalase, albumin, transferrin, and free thiols differed between active and inactive UC. Vitamins and carotenoids likewise emerged as potential disease activity biomarkers for CD and UC, but their intake should be monitored to obtain meaningful results. These findings emphasize the involvement of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers as a minimally invasive and additional tool for monitoring the activity of IBD. inflammatory bowel disease ulcerative colitis Crohn's disease oxidative stress biomarker meta-analysis vnetna črevesna bolezen biomarkerji meta-analiza true false true Angleški jezik Slovenski jezik Neznano 2026-07-01 13:24:22 2026-07-01 13:24:23 2026-07-03 03:46:48 0000-00-00 00:00:00 2024 0 0 Nasl. z nasl. zaslona; Opis vira z dne 2. 10. 2024; 14 str. article no. 103380 Vol. 77 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612.015:616.1/.4-036.1 2213-2317 10.1016/j.redox.2024.103380 209789443 RAZ_Tratensek_Armando_2024.pdf RAZ_Tratensek_Armando_2024.pdf 1 B563DA0646E76487A1B2486C1F6D0A46 16c7f513cfd450a5a50c43925d9d3ea0cad4571b6aa3b109ebed80e8ad5e3c9b 87a08a50-75d3-11f1-a2b4-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46983 https://www.sciencedirect.com/science/article/pii/S2213231724003586 1 69c1b416-753f-11f1-80d9-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=46921 Univerzitetni klinični center Ljubljana 0 0 0