| Naslov: | Defining remission in childhood-onset lupus : PReS-endorsed consensus definitions by an international task force |
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| Avtorji: | ID Smith, Eve Mary Dorothy (Avtor)
ID Aggarwal, Amita (Avtor)
ID Ainsworth, Jenny (Avtor)
ID Al-Abadi, Eslam (Avtor)
ID Avčin, Tadej (Avtor)
ID Bortey, Lynette (Avtor)
ID Burnham, Jon (Avtor)
ID Ciurtin, Coziana (Avtor)
ID Hedrich, Christian M. (Avtor)
ID Kamphuis, Sylvia (Avtor), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (767,89 KB)
MD5: 123E1FD34CC7DDAA26DDA6C4B78AE164
 URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S1521661624001050
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Method:s The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research. |
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| Ključne besede: | autoinflammatory diseases, lupus, treat-to-target, remission, children |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2024 |
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| Št. strani: | str. 1-9 |
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| Številčenje: | Vol 263 |
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| PID: | 20.500.12556/DiRROS-29776  |
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| UDK: | 616-097 |
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| ISSN pri članku: | 1521-6616 |
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| DOI: | 10.1016/j.clim.2024.110214 |
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| COBISS.SI-ID: | 205657859 |
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| Opomba: |
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| Datum objave v DiRROS: | 05.06.2026 |
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| Število ogledov: | 52 |
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| Število prenosov: | 32 |
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| Metapodatki: |    |
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