20.500.12556/DiRROS-29776 Defining remission in childhood-onset lupus PReS-endorsed consensus definitions by an international task force Objective: To derive childhood-onset SLE (cSLE) specific remission definitions for future treat-to-target (T2T) trials, observational studies, and clinical practice. Method:s The cSLE International T2T Task Force conducted Delphi surveys exploring paediatric perspectives on adult-onset SLE remission targets. A modified nominal group technique was used to discuss, refine, and agree on the cSLE remission target criteria. Results: The Task Force proposed two definitions of remission: ‘cSLE clinical remission on steroids (cCR)’ and ‘cSLE clinical remission off steroids (cCR-0)’. The common criteria are: (1) Clinical-SLEDAI-2 K = 0; (2) PGA score < 0.5 (0–3 scale); (4) stable antimalarials, immunosuppressive, and biologic therapy (changes due to side-effects, adherence, weight, or when building up to target dose allowed). Criterion (3) in cCR is the prednisolone dose ≤0.1 mg/kg/day (maximum 5 mg/day), whereas in cCR-0 it is zero. Conclusions: cSLE definitions of remission have been proposed, maintaining sufficient alignment with the adult-SLE definition to facilitate life-course research. autoinflammatory diseases lupus treat-to-target remission children true false true Angleški jezik Ni določen Neznano 2026-06-05 09:24:56 2026-06-05 09:24:56 2026-06-06 03:58:30 0000-00-00 00:00:00 2024 0 0 str. 1-9 Vol 263 Jun 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-097 1521-6616 10.1016/j.clim.2024.110214 205657859 RAZ_Smith_Eve_Mary_Dorothy_2024.pdf RAZ_Smith_Eve_Mary_Dorothy_2024.pdf 1 123E1FD34CC7DDAA26DDA6C4B78AE164 f4bc279ff05df4ba1e57d70939329aecf55eeba1529c06536f4d12ea74a9e924 cd000bc8-60af-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44761 https://www.sciencedirect.com/science/article/pii/S1521661624001050 0 a981f7cd-60af-11f1-9215-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=44760 Univerzitetni klinični center Ljubljana 0 0 0