| Naslov: | The association between periodontal inflamed surface area (PISA), inflammatory biomarkers, and mitochondrial DNA copy number |
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| Avtorji: | ID Mance Kristan, Romana (Avtor)
ID Jurgec, Staša (Avtor)
ID Potočnik, Uroš (Avtor)
ID Marhl, Marko (Avtor)
ID Gašperšič, Rok (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (307,60 KB)
MD5: 343B01B6521884BE63290BB1694AB929
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2077-0383/14/1/24
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Background/Objectives: Periodontitis is an inflammatory disease induced by bacteria in dental plaque that can activate the host’s immune-inflammatory response and invade the bloodstream. We hypothesized that a higher periodontal inflamed surface area (PISA) is associated with higher levels of inflammatory biomarkers, lower levels of antioxidants, and mitochondrial DNA copy number (mtDNAcn). Methods: Using periodontal parameters, we calculated the PISA score, measured the levels of inflammatory biomarkers and antioxidants in the serum, and took buccal swabs for mtDNA and nuclear DNA (nDNA) extraction. Results: Higher PISA was associated with higher CRP levels, higher leukocyte, neutrophil, and erythrocyte counts, and lower magnesium-to-calcium ratio, but not with mtDNAcn. A higher number of deep pockets was associated with higher leukocytes and neutrophil counts and higher uric acid levels. Conclusions: The PISA score might be an appropriate parameter to assess the inflammatory burden of periodontitis, but not to assess mitochondrial dysfunction after mtDNA isolation from buccal swabs. |
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| Ključne besede: | PISA, mitochondrial DNA copy number, mtDNA buccal swab, oxidative biomarkers |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2025 |
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| Št. strani: | str. 1-19 |
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| Številčenje: | Vol. 14, iss. 1, [article no.] 24 |
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| PID: | 20.500.12556/DiRROS-28976  |
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| UDK: | 616.3 |
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| ISSN pri članku: | 2077-0383 |
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| DOI: | 10.3390/jcm14010024 |
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| COBISS.SI-ID: | 221396995 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 8. 1. 2025;
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| Datum objave v DiRROS: | 15.04.2026 |
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| Število ogledov: | 82 |
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| Število prenosov: | 60 |
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| Metapodatki: |    |
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