| Naslov: | Advanced LC-MS/MS methodologies for the analysis of neuroactive compounds in tomato-based diets : insights from 2D in vitro digestion models |
|---|
| Avtorji: | ID Kovačič, Ana, Institut "Jožef Stefan" (Avtor)
ID Masuero, Domenico (Avtor)
ID Garcia-Aloy, Mar (Avtor)
ID Mancini, Andrea (Avtor)
ID Vrhovšek, Urška (Avtor) |
|---|
| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.sciencedirect.com/science/article/pii/S2772753X26000146?via%3Dihub
 PDF - Predstavitvena datoteka, prenos (2,85 MB)
MD5: 6D31D06AA67A0650EE61BB80A58D1EAF
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  IJS - Institut Jožef Stefan
|
|---|
| Povzetek: | The digestive fate of neuroactive food compounds remains poorly understood despite growing interest in their role in brain health. This study developed advanced analytical methods to identify neuroprotective and neuro-disrupting compounds in tomatoes before and after digestion and following fecal fermentation. Using in vitro digestion and fermentation models, we characterized compound behavior during digestion. Most compounds were quantified in undigested tomatoes. Digestion revealed diverse outcomes: some compounds transformed (e.g., chlorogenic acids), others produced (e.g., linoleic acid), and several remained stable with potential to reach the colon (e.g., serotonin, rutin). Notably, neuro-disrupting compounds like bisphenols remained largely unaltered and bioaccessible in the colon. Fecal fermentation further showed dynamic changes, with some compounds decreasing (e.g., rutin) and others increasing (e.g., quercetin). These findings provide both methodological advances and mechanistic insights into neuroactive compound behavior during digestion, informing future research on gut-mediated dietary effects in the context of neurodegenerative disease prevention. |
|---|
| Ključne besede: | neuroactive compounds, fecal fermentation, target analysis, bioaccesibility |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Poslano v recenzijo: | 16.11.2025 |
|---|
| Datum sprejetja članka: | 20.01.2026 |
|---|
| Datum objave: | 20.01.2026 |
|---|
| Založnik: | Elsevier |
|---|
| Leto izida: | 2026 |
|---|
| Št. strani: | str. 1-25 |
|---|
| Številčenje: | Vol. , [article no.] 101231 |
|---|
| Izvor: | Nizozemska |
|---|
| PID: | 20.500.12556/DiRROS-27638  |
|---|
| UDK: | 543 |
|---|
| ISSN pri članku: | 2772-753X |
|---|
| DOI: | 10.1016/j.focha.2026.101231 |
|---|
| COBISS.SI-ID: | 266449923 |
|---|
| Avtorske pravice: | © 2026 The Authors. |
|---|
| Opomba: | Nasl. z nasl. zaslona;
Soavtorji iz Slovenije: Urška Vrhovšek;
Opis vira z dne 28. 1. 2026;
|
|---|
| Datum objave v DiRROS: | 17.02.2026 |
|---|
| Število ogledov: | 216 |
|---|
| Število prenosov: | 87 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
