| Naslov: | Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells |
|---|
| Avtorji: | ID Perišić, Milica, Institut "Jožef Stefan" (Avtor)
ID Sabotič, Jerica, Institut "Jožef Stefan" (Avtor)
ID Jewett, Anahid (Avtor)
ID Kos, Janko, Institut "Jožef Stefan" (Avtor) |
|---|
| Datoteke: |  URL - Izvorni URL, za dostop obiščite http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
URL - Izvorni URL, za dostop obiščite http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full
 PDF - Predstavitvena datoteka, prenos (5,16 MB)
MD5: 41D4ACA8BFDF7A9D1F7A0B944F2700EC
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.02 - Pregledni znanstveni članek |
|---|
| Organizacija: |  IJS - Institut Jožef Stefan
|
|---|
| Povzetek: | Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes. |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Poslano v recenzijo: | 10.10.2014 |
|---|
| Datum sprejetja članka: | 18.11.2014 |
|---|
| Datum objave: | 02.12.2014 |
|---|
| Založnik: | Frontiers |
|---|
| Leto izida: | 2014 |
|---|
| Št. strani: | art. 616 |
|---|
| Številčenje: | Vol. 5 |
|---|
| Izvor: | Švica |
|---|
| PID: | 20.500.12556/DiRROS-23482  |
|---|
| UDK: | 577.27:616-097 |
|---|
| ISSN pri članku: | 1664-3224 |
|---|
| DOI: | 10.3389/fimmu.2014.00616 |
|---|
| COBISS.SI-ID: | 3788913 |
|---|
| Avtorske pravice: | © 2014 Periši ́c Nanut, Sabotiˇc, Jewett and Kos. |
|---|
| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 12. 2014;
Članek v pdf obsega 10 str.;
|
|---|
| Datum objave v DiRROS: | 04.09.2025 |
|---|
| Število ogledov: | 281 |
|---|
| Število prenosov: | 204 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
