20.500.12556/DiRROS-23482 Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells Cysteine cathepsins are lysosomal peptidases involved at different levels in the processes of the innate and adaptive immune responses. Some, such as cathepsins B, L, and H are expressed constitutively in most immune cells. In cells of innate immunity they play a role in cell adhesion and phagocytosis. Other cysteine cathepsins are expressed more specifically. Cathepsin X promotes dendritic cell maturation, adhesion of macrophages, and migration of T cells. Cathepsin S is implicated in major histocompatibility complex class II antigen presentation, whereas cathepsin C, expressed in cytotoxic T lymphocytes and natural killer (NK) cells, is involved in processing pro-granzymes into proteolytically active forms, which trigger cell death in their target cells. The activity of cysteine cathepsins is controlled by endogenous cystatins, cysteine protease inhibitors. Of these, cystatin F is the only cystatin that is localized in endosomal/lysosomal vesicles. After proteolytic removal of its N-terminal peptide, cystatin F becomes a potent inhibitor of cathepsin C with the potential to regulate pro-granzyme processing and cell cytotoxicity. This review is focused on the role of cysteine cathepsins and their inhibitors in the molecular mechanisms leading to the cytotoxic activity of T lymphocytes and NK cells in order to address new possibilities for regulation of their function in pathological processes. katepsini cisteini citotoksičnost citotoksične T celice naravne celice ubijalke true false false Frontiers Švica Angleški jezik Slovenski jezik © 2014 Periši ́c Nanut, Sabotiˇc, Jewett and Kos. Neznano 2025-09-04 10:25:18 2025-09-04 10:25:18 2025-10-24 03:54:25 0000-00-00 00:00:00 2014 0 0 Nasl. z nasl. zaslona; Opis vira z dne 11. 12. 2014; Članek v pdf obsega 10 str.; art. 616 Vol. 5 2014 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2014-10-10 2014-11-18 2014-12-02 577.27:616-097 1664-3224 10.3389/fimmu.2014.00616 3788913 http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full 1 bb2bfae2-8968-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34730 http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00616/full 1 b4faa427-8968-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34729 RAZ_Perisic_Milica_2014.pdf RAZ_Perisic_Milica_2014.pdf 1 41D4ACA8BFDF7A9D1F7A0B944F2700EC c6bbc4e377bf7ec0503f6bd1b060e55b4e3ca241e14e75ec820d98125f0f09ef 8a859764-8969-11f0-9bb7-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=34731 Institut Jožef Stefan 0 0 0