| Naslov: | The impact of bone marrow involvement on prognosis in diffuse large B-cell lymphoma : an 18F-FDG PET/CT volumetric segmentation study |
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| Avtorji: | ID Doma, Andrej (Avtor)
ID Studen, Andrej (Avtor)
ID Jezeršek Novaković, Barbara (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2072-6694/16/22/3762
 PDF - Predstavitvena datoteka, prenos (3,39 MB)
MD5: 578771FD22F0D27D733925D390879A9A
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  OI - Onkološki inštitut Ljubljana
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| Povzetek: | Background: This study assessed the prognostic value of tumor burden in bone marrow (BM) and total disease (TD), as depicted on 18F-FDG PET/CT in 140 DLBCL patients, for complete remission after first-line systemic treatment (iCR) and 3- and 5-year overall survival (OS3 and OS5). Methods: Baseline 18F-FDG PET/CT scans of 140 DLBCL patients were segmented to quantify metabolic tumor volume (MTV), total lesion glycolysis (TLG), and SUVmax in BMI, findings elsewhere (XL), and TD. Results: Bone marrow involvement (BMI) presented in 35 (25%) patients. Median follow-up time was 47 months; 79 patients (56%) achieved iCR. iCR was significantly associated with TD MTV, XL MTV, BM PET positivity, and International Prognostic Index (IPI). OS3 was significantly worse with TD MTV, XL MTV, IPI, and age. OS5 was significantly associated with IPI, but not with MTVs and TLGs. Univariate factors predicting OS3 were XL MTV (hazard ratio [HR] = 1.29), BMI SUVmax (HR = 0.56), and IPI (HR = 1.92). By multivariate analysis, higher IPI (HR = 2.26) and BMI SUVmax (HR = 0.91) were significant independent predictors for OS3. BMI SUVmax resulted in a negative coefficient and hence indicated a protective effect. Conclusions: Baseline 18F-FDG PET/CT MTV is significantly associated with survival. BMI identified on 18F-FDG PET/CT allows appropriate treatment that may improve survival. |
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| Ključne besede: | bone marrow, diffuse large B-cell lymphoma, survival |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.01.2024 |
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| Kraj izida: | Basel |
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| Založnik: | MDPI |
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| Leto izida: | 2024 |
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| Št. strani: | str. 3762-1-3762-17 |
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| Številčenje: | ǂVol.ǂ16, no. 22 |
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| Izvor: | Basel, Switzerland |
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| UDK: | 616.4 |
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| ISSN pri članku: | 2072-6694 |
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| DOI: | 10.3390/cancers16223762  |
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| COBISS.SI-ID: | 214486531 |
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| Avtorske pravice: | by Authors |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 11. 11. 2024;
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| Datum objave v DiRROS: | 09.01.2025 |
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| Število ogledov: | 19 |
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| Število prenosov: | 8 |
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| Metapodatki: |    |
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