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Title:The impact of bone marrow involvement on prognosis in diffuse large B-cell lymphoma : an 18F-FDG PET/CT volumetric segmentation study
Authors:ID Doma, Andrej (Author)
ID Studen, Andrej (Author)
ID Jezeršek Novaković, Barbara (Author)
Files:URL URL - Source URL, visit https://www.mdpi.com/2072-6694/16/22/3762
 
.pdf PDF - Presentation file, download (3,39 MB)
MD5: 578771FD22F0D27D733925D390879A9A
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo OI - Institute of Oncology
Abstract:Background: This study assessed the prognostic value of tumor burden in bone marrow (BM) and total disease (TD), as depicted on 18F-FDG PET/CT in 140 DLBCL patients, for complete remission after first-line systemic treatment (iCR) and 3- and 5-year overall survival (OS3 and OS5). Methods: Baseline 18F-FDG PET/CT scans of 140 DLBCL patients were segmented to quantify metabolic tumor volume (MTV), total lesion glycolysis (TLG), and SUVmax in BMI, findings elsewhere (XL), and TD. Results: Bone marrow involvement (BMI) presented in 35 (25%) patients. Median follow-up time was 47 months; 79 patients (56%) achieved iCR. iCR was significantly associated with TD MTV, XL MTV, BM PET positivity, and International Prognostic Index (IPI). OS3 was significantly worse with TD MTV, XL MTV, IPI, and age. OS5 was significantly associated with IPI, but not with MTVs and TLGs. Univariate factors predicting OS3 were XL MTV (hazard ratio [HR] = 1.29), BMI SUVmax (HR = 0.56), and IPI (HR = 1.92). By multivariate analysis, higher IPI (HR = 2.26) and BMI SUVmax (HR = 0.91) were significant independent predictors for OS3. BMI SUVmax resulted in a negative coefficient and hence indicated a protective effect. Conclusions: Baseline 18F-FDG PET/CT MTV is significantly associated with survival. BMI identified on 18F-FDG PET/CT allows appropriate treatment that may improve survival.
Keywords:bone marrow, diffuse large B-cell lymphoma, survival
Publication version:Version of Record
Publication date:01.01.2024
Place of publishing:Basel
Publisher:MDPI
Year of publishing:2024
Number of pages:str. 3762-1-3762-17
Numbering:ǂVol.ǂ16, no. 22
Source:Basel, Switzerland
PID:20.500.12556/DiRROS-21160 New window
UDC:616.4
ISSN on article:2072-6694
DOI:10.3390/cancers16223762 New window
COBISS.SI-ID:214486531 New window
Copyright:by Authors
Note:Nasl. z nasl. zaslona; Opis vira z dne 11. 11. 2024;
Publication date in DiRROS:09.01.2025
Views:214
Downloads:122
Metadata:XML DC-XML DC-RDF
:
DOMA, Andrej, STUDEN, Andrej and JEZERŠEK NOVAKOVIĆ, Barbara, 2024, The impact of bone marrow involvement on prognosis in diffuse large B-cell lymphoma : an 18F-FDG PET/CT volumetric segmentation study. Cancers [online]. 2024. Vol. 16, no. 22, p. 3762-1-3762–17. [Accessed 8 April 2025]. DOI 10.3390/cancers16223762. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=21160
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Record is a part of a journal

Title:Cancers
Shortened title:Cancers
Publisher:MDPI
ISSN:2072-6694
COBISS.SI-ID:517914137 New window

Document is financed by a project

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P3-0321-2020
Name:Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka
Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P1-0389-2022
Name:Medicinska fizika

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:kostni mozeg, difuzni velikocelični limfom B, preživetje


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