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Naslov:Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts
Avtorji:ID Murgia, Marta (Avtor)
ID Rittweger, Joern (Avtor)
ID Reggiani, Carlo (Avtor)
ID Bottinelli, Roberto (Avtor)
ID Mann, Matthias (Avtor)
ID Schiaffino, Stefano (Avtor)
ID Narici, Marco Vicenzo (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1038/s41526-024-00406-3
 
URL URL - Izvorni URL, za dostop obiščite https://www.nature.com/articles/s41526-024-00406-3#citeas
 
.pdf PDF - Predstavitvena datoteka, prenos (1,55 MB)
MD5: 39F2BB903A39772247E8122584C0BB9F
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo ZRS Koper - Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria
Povzetek:Skeletal muscle undergoes atrophy and loss of force during long space missions, when astronauts are persistently exposed to altered gravity and increased ionizing radiation. We previously carried out mass spectrometry-based proteomics from skeletal muscle biopsies of two astronauts, taken before and after a mission on the International Space Station. The experiments were part of an effort to find similarities between spaceflight and bed rest, a ground-based model of unloading, focused on proteins located at the costameres. We here extend the data analysis of the astronaut dataset and show compartment-resolved changes in the mitochondrial proteome, remodeling of the extracellular matrix and of the antioxidant response. The astronauts differed in their level of onboard physical exercise, which correlated with their respective preservation of muscle mass and force at landing in previous analyses. We show that the mitochondrial proteome downregulation during spaceflight, particularly the inner membrane and matrix, was dramatic for both astronauts. The expression of autophagy regulators and reactive oxygen species scavengers, however, showed partially opposite expression trends in the two subjects, possibly correlating with their level of onboard exercise. As mitochondria are primarily affected in many different tissues during spaceflight, we hypothesize that reactive oxygen species (ROS) rather than mechanical unloading per se could be the primary cause of skeletal muscle mitochondrial damage in space. Onboard physical exercise might have a strong direct effect on the prevention of muscle atrophy through mechanotransduction and a subsidiary effect on mitochondrial quality control, possibly through upregulation of autophagy and anti-oxidant responses.
Ključne besede:skeletal muscles, microgravity, muscle atrophy, autophagy
Datum sprejetja članka:22.05.2024
Datum objave:01.01.2024
Leto izida:2024
Št. strani:str. 1-13
Številčenje:Vol. 10, [art. no.] 60
UDK:612.74
ISSN pri članku:2373-8065
DOI:10.1038/s41526-024-00406-3 Novo okno
COBISS.SI-ID:214714115 Novo okno
Opomba:Opis vira z dne 12. 11. 2024; Nasl. z nasl. zaslona;
Datum objave v DiRROS:12.11.2024
Število ogledov:15
Število prenosov:8
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Gradivo je del revije

Naslov:NPJ microgravity
Skrajšan naslov:NPJ microgravity
Založnik:Nature Publishing Group ;, Biodesign Institute at Arizona State University
ISSN:2373-8065
COBISS.SI-ID:525387289 Novo okno

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:05.06.2024

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Jezik:Slovenski jezik
Ključne besede:skeletne mišice, mikrogravitacija, atrofija mišic, avtofagija


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