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Title:Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts
Authors:ID Murgia, Marta (Author)
ID Rittweger, Joern (Author)
ID Reggiani, Carlo (Author)
ID Bottinelli, Roberto (Author)
ID Mann, Matthias (Author)
ID Schiaffino, Stefano (Author)
ID Narici, Marco Vicenzo (Author)
Files:URL URL - Source URL, visit https://www.nature.com/articles/s41526-024-00406-3#citeas
 
URL URL - Source URL, visit https://doi.org/10.1038/s41526-024-00406-3
 
.pdf PDF - Presentation file, download (1,55 MB)
MD5: 39F2BB903A39772247E8122584C0BB9F
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo ZRS Koper - Science and Research Centre Koper
Abstract:Skeletal muscle undergoes atrophy and loss of force during long space missions, when astronauts are persistently exposed to altered gravity and increased ionizing radiation. We previously carried out mass spectrometry-based proteomics from skeletal muscle biopsies of two astronauts, taken before and after a mission on the International Space Station. The experiments were part of an effort to find similarities between spaceflight and bed rest, a ground-based model of unloading, focused on proteins located at the costameres. We here extend the data analysis of the astronaut dataset and show compartment-resolved changes in the mitochondrial proteome, remodeling of the extracellular matrix and of the antioxidant response. The astronauts differed in their level of onboard physical exercise, which correlated with their respective preservation of muscle mass and force at landing in previous analyses. We show that the mitochondrial proteome downregulation during spaceflight, particularly the inner membrane and matrix, was dramatic for both astronauts. The expression of autophagy regulators and reactive oxygen species scavengers, however, showed partially opposite expression trends in the two subjects, possibly correlating with their level of onboard exercise. As mitochondria are primarily affected in many different tissues during spaceflight, we hypothesize that reactive oxygen species (ROS) rather than mechanical unloading per se could be the primary cause of skeletal muscle mitochondrial damage in space. Onboard physical exercise might have a strong direct effect on the prevention of muscle atrophy through mechanotransduction and a subsidiary effect on mitochondrial quality control, possibly through upregulation of autophagy and anti-oxidant responses.
Keywords:skeletal muscles, microgravity, muscle atrophy, autophagy
Article acceptance date:22.05.2024
Publication date:01.01.2024
Year of publishing:2024
Number of pages:str. 1-13
Numbering:Vol. 10, [art. no.] 60
PID:20.500.12556/DiRROS-20827 New window
UDC:612.74
ISSN on article:2373-8065
DOI:10.1038/s41526-024-00406-3 New window
COBISS.SI-ID:214714115 New window
Note:Opis vira z dne 12. 11. 2024; Nasl. z nasl. zaslona;
Publication date in DiRROS:12.11.2024
Views:127
Downloads:73
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Record is a part of a journal

Title:NPJ microgravity
Shortened title:NPJ microgravity
Publisher:Nature Publishing Group ;, Biodesign Institute at Arizona State University
ISSN:2373-8065
COBISS.SI-ID:525387289 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:05.06.2024

Secondary language

Language:Slovenian
Keywords:skeletne mišice, mikrogravitacija, atrofija mišic, avtofagija


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