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Naslov:Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes : a contribution to the understanding of the systemic toxicity of cyanotoxins
Avtorji:ID Bubik, Anja (Avtor)
ID Frangež, Robert (Avtor)
ID Žužek, Monika C. (Avtor)
ID Gutiérrez-Aguirre, Ion (Avtor)
ID Lah Turnšek, Tamara (Avtor)
ID Sedmak, Bojan (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.3390/toxins16090374
 
.pdf PDF - Predstavitvena datoteka, prenos (21,09 MB)
MD5: E7C76924AF8B510314F095D2393A909B
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:The systemic toxicity of cyclic peptides produced by cyanobacteria (CCPs) is not yet completely understood. Apart from the most known damages to the liver and kidneys, symptoms of their neurotoxicity have also been reported. Hepatotoxic CCPs, like microcystins, as well as non-hepatotoxic anabaenopeptins and planktopeptins, all exhibit cytotoxic and cytostatic effects on mammalian cells. However, responses of different cell types to CCPs depend on their specific modes of interaction with cell membranes. This study demonstrates that non-hepatotoxic planktopeptin BL1125 and anabaenopeptins B and F, at concentrations up to 10 µM, affect normal and tumor human astrocytes (NHA and U87-GM) in vitro by their almost immediate insertion into the lipid monolayer. Like microcystin-LR (up to 1 µM), they inhibit Ser/Thr phosphatases and reorganize cytoskeletal elements, with modest effects on their gene expression. Based on the observed effects on intermediate filaments and intermediate filament linkage elements, their direct or indirect influence on tubulin cytoskeletons via post-translational modifications, we conclude that the basic mechanism of CCP toxicities is the induction of inter- and intracellular communication failure. The assessed inhibitory activity on Ser/Thr phosphatases is also crucial since the signal transduction cascades are modulated by phosphorylation/dephosphorylation processes.
Ključne besede:astrocytes, cyclic cyanobacterial peptides, cytoskeletal organization, Ser/Thr phosphatases, systemic toxicity, cyanobacteria
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.09.2024
Leto izida:2024
Št. strani:str. 1-18
Številčenje:iss. 9, [art no.] ǂ374
PID:20.500.12556/DiRROS-20241 Novo okno
UDK:576
ISSN pri članku:2072-6651
DOI:10.3390/toxins16090374 Novo okno
COBISS.SI-ID:205590019 Novo okno
Opomba:Soavtorji: Robert Frangež, Monika C. Žužek, Ion Gutiérrez-Aguirre, Tamara T. Lah and Bojan Sedmak; Nasl. z nasl. zaslona; Opis vira z dne 28. 8. 2024;
Datum objave v DiRROS:28.08.2024
Število ogledov:588
Število prenosov:425
Metapodatki:XML DC-XML DC-RDF
:
BUBIK, Anja, FRANGEŽ, Robert, ŽUŽEK, Monika C., GUTIÉRREZ-AGUIRRE, Ion, LAH TURNŠEK, Tamara in SEDMAK, Bojan, 2024, Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes : a contribution to the understanding of the systemic toxicity of cyanotoxins. Toxins : Elektronski vir [na spletu]. 2024. Vol. 9, no. art  374, p. 1–18. [Dostopano 30 marec 2025]. DOI 10.3390/toxins16090374. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20241
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Gradivo je del revije

Naslov:Toxins : Elektronski vir
Skrajšan naslov:Toxins
Založnik:MDPI
ISSN:2072-6651
COBISS.SI-ID:517594649 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J1-0848-2008
Naslov:Antikancerogeno delovanje bioaktivnih spojin cianobakterijskega izvora v nasprotju možganskih tumorjev - gliobastomov
Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P4-0053-2019
Naslov:Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih
Financer:Drugi - Drug financer ali več financerjev
Program financ.:Ministry of Defense, Administration for Civil Protection and Disaster Relief
Številka projekta:URSZR 4300-1117/2009-1

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Naslov:Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes – a contribution to the understanding of the systemic toxicity of cyanotoxins
Ključne besede:astrociti, ciklični cianobakterijski peptidi, citoskeletna organizacija, Ser/Thr fosfataze, sistemska toksičnost, cianobakterije


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