| Naslov: | Synthesis, purification, and cell-toxicity of a choline betainate |
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| Avtorji: | ID Jurko, Lucija (Avtor)
ID Hostnik, Gregor (Avtor)
ID Steindorfer, Tobias Alexander (Avtor)
ID Štern, Alja (Avtor)
ID Bošković, Perica (Avtor)
ID Bračič, Matej (Avtor)
ID Žegura, Bojana (Avtor)
ID Kargl, Rupert (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (3,60 MB)
MD5: F137BF01D4EA39F4FFE15311D3926E37
 URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.molstruc.2024.138581
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug. |
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| Ključne besede: | choline chloride, betaine hydrochloride, carbonyldiimidazole, HPLC, antimicrobial, cytotoxicity |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 15.09.2024 |
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| Leto izida: | 2024 |
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| Št. strani: | [16] str. |
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| Številčenje: | [article no.] 138581 |
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| PID: | 20.500.12556/DiRROS-20183  |
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| UDK: | 577:576 |
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| ISSN pri članku: | 1872-8014 |
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| DOI: | 10.1016/j.molstruc.2024.138581 |
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| COBISS.SI-ID: | 195589379 |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorji: Gregor Hostnik , Tobias Steindorfer, Alja Štern, Perica Bošković, Matej Bračič, Bojana Žegura, Rupert Kargl;
In Press, Journal pre-proof;
Opis vira z dne 16. 5. 2024;
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| Datum objave v DiRROS: | 07.08.2024 |
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| Število ogledov: | 307 |
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| Število prenosov: | 342 |
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| Metapodatki: |    |
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