| Title: | Synthesis, purification, and cell-toxicity of a choline betainate |
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| Authors: | ID Jurko, Lucija (Author)
ID Hostnik, Gregor (Author)
ID Steindorfer, Tobias Alexander (Author)
ID Štern, Alja (Author)
ID Bošković, Perica (Author)
ID Bračič, Matej (Author)
ID Žegura, Bojana (Author)
ID Kargl, Rupert (Author) |
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| Files: |  PDF - Presentation file, download (3,60 MB)
MD5: F137BF01D4EA39F4FFE15311D3926E37
 URL - Source URL, visit https://doi.org/10.1016/j.molstruc.2024.138581
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| Language: | English |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: |  NIB - National Institute of Biology
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| Abstract: | In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug. |
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| Keywords: | choline chloride, betaine hydrochloride, carbonyldiimidazole, HPLC, antimicrobial, cytotoxicity |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 15.09.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | [16] str. |
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| Numbering: | [article no.] 138581 |
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| PID: | 20.500.12556/DiRROS-20183  |
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| UDC: | 577:576 |
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| ISSN on article: | 1872-8014 |
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| DOI: | 10.1016/j.molstruc.2024.138581 |
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| COBISS.SI-ID: | 195589379 |
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| Note: | Nasl. z nasl. zaslona;
Soavtorji: Gregor Hostnik , Tobias Steindorfer, Alja Štern, Perica Bošković, Matej Bračič, Bojana Žegura, Rupert Kargl;
In Press, Journal pre-proof;
Opis vira z dne 16. 5. 2024;
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| Publication date in DiRROS: | 07.08.2024 |
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| Views: | 309 |
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| Downloads: | 342 |
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