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Naslov:Endothelial tip cells in ocular angiogenesis : potential target for anti-angiogenesis therapy
Avtorji:ID Siemerink, Martin J. (Avtor)
ID Klaassen, Ingeborg (Avtor)
ID Noorden, Cornelis J. F. van (Avtor)
ID Schlingemann, Reinier O. (Avtor)
Datoteke:URL URL - Izvorni URL, za dostop obiščite https://doi.org/10.1369/0022155412467635
 
.pdf PDF - Predstavitvena datoteka, prenos (816,40 KB)
MD5: 7FFF21AD061884866D45F0937838E4CC
 
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pathological blood vessels in proliferative retinopathies. Tip cells control adjacent endothelial cells in a hierarchical manner to form the stalk of the sprouting vessel, using, among others, the VEGF-DLL-Notch signaling pathway, and recruit pericytes. Tip cells are guided toward avascular areas by signals from the local extracellular matrix that are released by cells from the neuroretina such as astrocytes. Recently, tip cells were identified in endothelial cell cultures, enabling identification of novel molecular markers and mechanisms involved in tip cell biology. These mechanisms are relevant for understanding proliferative retinopathies. Agents that primarily target tip cells can block pathological angiogenesis in the retina efficiently and safely without adverse effects. A striking example is platelet-derived growth factor, which was recently shown to be an efficacious additional target in the treatment of retinal neovascularization. Here we discuss these and other tip cell-based strategies with respect to their potential to treat patients with ocular diseases dominated by neovascularization.
Ključne besede:angiogenesis, endothelial tip cell, proliferative retinopathy, anti-angiogenesis therapy, retinal neovascularization, vascular sprouts, endothelial stalk cell, molecular mediators of angiogenesis, pericytes
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.02.2013
Leto izida:2013
Št. strani:str. 101-115
Številčenje:Vol. 61, iss. 2
PID:20.500.12556/DiRROS-20025 Novo okno
UDK:577.2
ISSN pri članku:0022-1554
DOI:10.1369/0022155412467635 Novo okno
COBISS.SI-ID:4648783 Novo okno
Datum objave v DiRROS:02.08.2024
Število ogledov:500
Število prenosov:276
Metapodatki:XML DC-XML DC-RDF
:
SIEMERINK, Martin J., KLAASSEN, Ingeborg, NOORDEN, Cornelis J. F. van in SCHLINGEMANN, Reinier O., 2013, Endothelial tip cells in ocular angiogenesis : potential target for anti-angiogenesis therapy. The Journal of histochemistry and cytochemistry [na spletu]. 2013. Vol. 61, no. 2, p. 101–115. [Dostopano 6 april 2025]. DOI 10.1369/0022155412467635. Pridobljeno s: https://dirros.openscience.si/IzpisGradiva.php?lang=slv&id=20025
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Gradivo je del revije

Naslov:The Journal of histochemistry and cytochemistry
Skrajšan naslov:J Histochem Cytochem
Založnik:Williams & Wilkins Co.
ISSN:0022-1554
COBISS.SI-ID:6404615 Novo okno

Gradivo je financirano iz projekta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Retina Nederland Onderzoek Fonds, Stichting MD Fonds,
Številka projekta:2009-18
Naslov:Uitzicht

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Licenca:CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
Povezava:https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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