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Title:Endothelial tip cells in ocular angiogenesis : potential target for anti-angiogenesis therapy
Authors:ID Siemerink, Martin J. (Author)
ID Klaassen, Ingeborg (Author)
ID Noorden, Cornelis J. F. van (Author)
ID Schlingemann, Reinier O. (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1369/0022155412467635
 
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MD5: 7FFF21AD061884866D45F0937838E4CC
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pathological blood vessels in proliferative retinopathies. Tip cells control adjacent endothelial cells in a hierarchical manner to form the stalk of the sprouting vessel, using, among others, the VEGF-DLL-Notch signaling pathway, and recruit pericytes. Tip cells are guided toward avascular areas by signals from the local extracellular matrix that are released by cells from the neuroretina such as astrocytes. Recently, tip cells were identified in endothelial cell cultures, enabling identification of novel molecular markers and mechanisms involved in tip cell biology. These mechanisms are relevant for understanding proliferative retinopathies. Agents that primarily target tip cells can block pathological angiogenesis in the retina efficiently and safely without adverse effects. A striking example is platelet-derived growth factor, which was recently shown to be an efficacious additional target in the treatment of retinal neovascularization. Here we discuss these and other tip cell-based strategies with respect to their potential to treat patients with ocular diseases dominated by neovascularization.
Keywords:angiogenesis, endothelial tip cell, proliferative retinopathy, anti-angiogenesis therapy, retinal neovascularization, vascular sprouts, endothelial stalk cell, molecular mediators of angiogenesis, pericytes
Publication status:Published
Publication version:Version of Record
Publication date:01.02.2013
Year of publishing:2013
Number of pages:str. 101-115
Numbering:Vol. 61, iss. 2
PID:20.500.12556/DiRROS-20025 New window
UDC:577.2
ISSN on article:0022-1554
DOI:10.1369/0022155412467635 New window
COBISS.SI-ID:4648783 New window
Publication date in DiRROS:02.08.2024
Views:513
Downloads:279
Metadata:XML DC-XML DC-RDF
:
SIEMERINK, Martin J., KLAASSEN, Ingeborg, NOORDEN, Cornelis J. F. van and SCHLINGEMANN, Reinier O., 2013, Endothelial tip cells in ocular angiogenesis : potential target for anti-angiogenesis therapy. The Journal of histochemistry and cytochemistry [online]. 2013. Vol. 61, no. 2, p. 101–115. [Accessed 9 April 2025]. DOI 10.1369/0022155412467635. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=20025
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Record is a part of a journal

Title:The Journal of histochemistry and cytochemistry
Shortened title:J Histochem Cytochem
Publisher:Williams & Wilkins Co.
ISSN:0022-1554
COBISS.SI-ID:6404615 New window

Document is financed by a project

Funder:Other - Other funder or multiple funders
Funding programme:Retina Nederland Onderzoek Fonds, Stichting MD Fonds,
Project number:2009-18
Name:Uitzicht

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License:CC BY-NC 3.0, Creative Commons Attribution-NonCommercial 3.0 Unported
Link:http://creativecommons.org/licenses/by-nc/3.0/
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