| Naslov: | Nanoscale transformations of amphiboles within human alveolar epithelial cells |
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| Avtorji: | ID Vigliaturo, Ruggero (Avtor)
ID Jamnik, Maja (Avtor)
ID Dražić, Goran (Avtor)
ID Podobnik, Marjetka (Avtor)
ID Tušek-Žnidarič, Magda (Avtor)
ID Della Ventura, Giancarlo (Avtor)
ID Redhammer, Günther (Avtor)
ID Žnidaršič, Nada (Avtor)
ID Caserman, Simon (Avtor)
ID Gieré, Reto (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://www.nature.com/articles/s41598-022-05802-x
 PDF - Predstavitvena datoteka, prenos (4,53 MB)
MD5: 2D177548C6517CBCD767E80AC514D728
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | Amphibole asbestos is related to lung fibrosis and several types of lung tumors. The disease-triggering mechanisms still challenge our diagnostic capabilities and are still far from being fully understood. The literature focuses primarily on the role and formation of asbestos bodies in lung tissues, but there is a distinct lack of studies on amphibole particles that have been internalized by alveolar epithelial cells (AECs). These internalized particles may directly interact with the cell nucleus and the organelles, exerting a synergistic action with asbestos bodies (AB) from a different location. Here we document the near-atomic- to nano-scale transformations induced by, and taking place within, AECs of three distinct amphiboles (anthophyllite, grunerite, “amosite”) with different Fe-content and morphologic features. We show that: (i) an Fe-rich layer is formed on the internalized particles, (ii) particle grain boundaries are transformed abiotically by the internal chemical environment of AECs and/or by a biologically induced mineralization mechanism, (iii) the Fe-rich material produced on the particle surface does not contain large amounts of P, in stark contrast to extracellular ABs, and (iv) the iron in the Fe-rich layer is derived from the particle itself. Internalized particles and ABs follow two distinct formation mechanisms reaching different physicochemical end-states. |
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| Ključne besede: | amphiboles, human alveolar epithelial cells, asbestos, lung cancer, nanoscale investigation, acS/TEM-EDXS, dual-EELS, asbestos-related tumors |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 02.02.2022 |
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| Leto izida: | 2022 |
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| Št. strani: | str. 1-14 |
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| Številčenje: | Vol. 12 |
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| PID: | 20.500.12556/DiRROS-19365  |
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| UDK: | 620.1/.2 |
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| ISSN pri članku: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-05802-x |
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| COBISS.SI-ID: | 96630275 |
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| Opomba: | Soavtorji: Maja Jamnik, Goran Dražić, Marjetka Podobnik, Magda Tušek Žnidarič, Giancarlo Della Ventura, Günther J. Redhammer, Nada Žnidaršič, Simon Caserman & Reto Gieré;
Nasl. z nasl. zaslona;
Opis vira z dne 9. 2. 2022;
Št. članka: 1782;
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| Datum objave v DiRROS: | 16.07.2024 |
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| Število ogledov: | 423 |
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| Število prenosov: | 245 |
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| Metapodatki: |    |
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