| Naslov: | Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells |
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| Avtorji: | ID Ko, Meng-Wei (Avtor)
ID Breznik, Barbara (Avtor)
ID Senjor, Emanuela (Avtor)
ID Jewett, Anahid (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.1016/j.adcanc.2022.100043
 PDF - Predstavitvena datoteka, prenos (8,37 MB)
MD5: 8BB1161F766362CA48EE4276CE48335F
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tumor cells. In addition, WIN 55,212-2 decreases cell surface expression of CD44, CD54, MHC class I and PD-L1 on oral and pancreatic tumor cells with the exception of PD-L1 expression on well-differentiated PL-12 pancreatic tumor cells which exhibits an increase in the expression rather than a decrease. Overall, we demonstrate that WIN 55,212-2 has an increased targeting activity against cancer stem cells/poorly differentiated oral and pancreatic tumor cells when compared to well-differentiated tumor cells, and furthermore, such differences in function do not correlate with the levels of CB1 and CB2 receptor expression on tumor cells, suggesting it's function either through post-receptor mediated activation and/or yet-to-be identified novel receptors. Intraperitoneal (IP) delivery of WIN 55-212-2 in humanized BLT mice is found to impart an activating potential for NK cells demonstrating increased NK cell mediated cytotoxicity and secretion of IFN-γ in our preliminary experiments. These results not only suggest a direct targeting of CSCs/poorly differentiated tumors by WIN 55-212-2 but also by indirect targeting of such tumors through the activation and increased functions of NK cells. |
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| Ključne besede: | cancer stem cells, cannabinoids, cell death, cancer biology, genetic toxicology |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 01.10.2022 |
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| Leto izida: | 2022 |
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| Št. strani: | str. [1]-10 |
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| Številčenje: | Vol. 5 |
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| PID: | 20.500.12556/DiRROS-19322  |
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| UDK: | 575 |
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| ISSN pri članku: | 2667-3940 |
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| DOI: | 10.1016/j.adcanc.2022.100043 |
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| COBISS.SI-ID: | 113550595 |
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| Opomba: | Ostali avtorji: Barbara Breznik, Emanuela Senjor, Anahid Jewett;
Nasl. z nasl. zaslona;
Opis vira z dne 1. 7. 2022;
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| Datum objave v DiRROS: | 17.07.2024 |
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| Število ogledov: | 5 |
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| Število prenosov: | 2 |
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| Metapodatki: |     |
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