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Title:Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells
Authors:ID Ko, Meng-Wei (Author)
ID Breznik, Barbara (Author)
ID Senjor, Emanuela (Author)
ID Jewett, Anahid (Author)
Files:URL URL - Source URL, visit https://doi.org/10.1016/j.adcanc.2022.100043
 
.pdf PDF - Presentation file, download (8,37 MB)
MD5: 8BB1161F766362CA48EE4276CE48335F
 
Language:English
Typology:1.01 - Original Scientific Article
Organization:Logo NIB - National Institute of Biology
Abstract:We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tumor cells. In addition, WIN 55,212-2 decreases cell surface expression of CD44, CD54, MHC class I and PD-L1 on oral and pancreatic tumor cells with the exception of PD-L1 expression on well-differentiated PL-12 pancreatic tumor cells which exhibits an increase in the expression rather than a decrease. Overall, we demonstrate that WIN 55,212-2 has an increased targeting activity against cancer stem cells/poorly differentiated oral and pancreatic tumor cells when compared to well-differentiated tumor cells, and furthermore, such differences in function do not correlate with the levels of CB1 and CB2 receptor expression on tumor cells, suggesting it's function either through post-receptor mediated activation and/or yet-to-be identified novel receptors. Intraperitoneal (IP) delivery of WIN 55-212-2 in humanized BLT mice is found to impart an activating potential for NK cells demonstrating increased NK cell mediated cytotoxicity and secretion of IFN-γ in our preliminary experiments. These results not only suggest a direct targeting of CSCs/poorly differentiated tumors by WIN 55-212-2 but also by indirect targeting of such tumors through the activation and increased functions of NK cells.
Keywords:cancer stem cells, cannabinoids, cell death, cancer biology, genetic toxicology
Publication status:Published
Publication version:Version of Record
Publication date:01.10.2022
Year of publishing:2022
Number of pages:str. [1]-10
Numbering:Vol. 5
PID:20.500.12556/DiRROS-19322 New window
UDC:575
ISSN on article:2667-3940
DOI:10.1016/j.adcanc.2022.100043 New window
COBISS.SI-ID:113550595 New window
Note:Ostali avtorji: Barbara Breznik, Emanuela Senjor, Anahid Jewett; Nasl. z nasl. zaslona; Opis vira z dne 1. 7. 2022;
Publication date in DiRROS:17.07.2024
Views:533
Downloads:285
Metadata:XML DC-XML DC-RDF
:
KO, Meng-Wei, BREZNIK, Barbara, SENJOR, Emanuela and JEWETT, Anahid, 2022, Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells. Advances in cancer biology : Metastasis [online]. 2022. Vol. 5, p. 1–10. [Accessed 10 April 2025]. DOI 10.1016/j.adcanc.2022.100043. Retrieved from: https://dirros.openscience.si/IzpisGradiva.php?lang=eng&id=19322
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Record is a part of a journal

Title:Advances in cancer biology : Metastasis
Publisher:Elsevier B.V.
ISSN:2667-3940
COBISS.SI-ID:87457795 New window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:rakave matične celice, kanabinoidi, celična smrt, biologija raka, genetska toksikologija


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