| Naslov: | Retinal venular vessel diameters are smaller during ten days of bed rest |
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| Avtorji: | ID Salon, Adam (Avtor)
ID Çiftci, Göktuğ Mert (Avtor)
ID Zubac, Damir (Avtor)
ID Šimunič, Boštjan (Avtor)
ID Pišot, Rado (Avtor)
ID Narici, Marco Vicenzo (Avtor)
ID Fredriksen, Per Morten (Avtor)
ID Nkeh-Chungag, Benedicta Ngwenchi (Avtor)
ID Sourij, Harald (Avtor)
ID Goswami, Nandu (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.1038/s41598-023-46177-x
 PDF - Predstavitvena datoteka, prenos (1,07 MB)
MD5: 48BB82B90006AC6869B25573482105A8
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  ZRS Koper - Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria
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| Povzetek: | Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spacefight. This study investigates changes in retinal microcirculation during a tenday bed rest protocol. Ten healthy young males (22.9± 4.7 years; body mass index: 23.6± 2.5 kg·m–2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a signifcant decrease in retinal venular diameter was observed, indicated by a signifcantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p= .026), while no signifcant changes in central retinal artery equivalent were noted. Prolonged bed rest confnement resulted in a signifcant (up to 6.5%) reduction in retinal venular diameter. These fndings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and refect overall (cardio)-vascular deconditioning. |
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| Ključne besede: | eyes, retinal venular vessel, venske žile, bed rest, gibalna neaktivnost |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 07.11.2023 |
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| Leto izida: | 2023 |
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| Št. strani: | 7 str. |
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| Številčenje: | Vol. 13, [article no. ] ǂ19258 |
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| PID: | 20.500.12556/DiRROS-17342  |
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| UDK: | 612 |
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| ISSN pri članku: | 2045-2322 |
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| DOI: | 10.1038/s41598-023-46177-x |
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| COBISS.SI-ID: | 173471747 |
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| Avtorske pravice: | © The Author(s) 2023 |
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| Opomba: | Nasl. z nasl. zaslona;
Soavtorji: Göktuğ Mert Çiftci, Damir Zubac, Boštjan Šimunič, Rado Pišot, Marco Narici, Per Morten Fredriksen, Benedicta Ngwenchi Nkeh-Chungag, Harald Sourij, Omar Šerý, Karin Schmid-Zalaudek, Bianca Steuber, Patrick De Boever & Nandu Goswami;
Opis vira z dne 23. 11. 2023; |
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| Datum objave v DiRROS: | 23.11.2023 |
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| Število ogledov: | 1114 |
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| Število prenosov: | 367 |
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| Metapodatki: |    |
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