20.500.12556/DiRROS-17342 Retinal venular vessel diameters are smaller during ten days of bed rest Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spacefight. This study investigates changes in retinal microcirculation during a tenday bed rest protocol. Ten healthy young males (22.9± 4.7 years; body mass index: 23.6± 2.5 kg·m–2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a signifcant decrease in retinal venular diameter was observed, indicated by a signifcantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p= .026), while no signifcant changes in central retinal artery equivalent were noted. Prolonged bed rest confnement resulted in a signifcant (up to 6.5%) reduction in retinal venular diameter. These fndings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and refect overall (cardio)-vascular deconditioning. eyes retinal venular vessel venske žile bed rest gibalna neaktivnost oko mrežnica venske žile ležanje v postelji gibalna neaktivnost true false true Angleški jezik Slovenski jezik © The Author(s) 2023 Neznano 2023-11-23 14:48:51 2023-11-23 14:48:53 2024-12-11 12:21:09 0000-00-00 00:00:00 2023 0 0 Nasl. z nasl. zaslona; Soavtorji: Göktuğ Mert Çiftci, Damir Zubac, Boštjan Šimunič, Rado Pišot, Marco Narici, Per Morten Fredriksen, Benedicta Ngwenchi Nkeh-Chungag, Harald Sourij, Omar Šerý, Karin Schmid-Zalaudek, Bianca Steuber, Patrick De Boever & Nandu Goswami; Opis vira z dne 23. 11. 2023; 7 str. [article no. ] ǂ19258 Vol. 13 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-11-07 612 2045-2322 10.1038/s41598-023-46177-x 173471747 ZRSKP_Zubac_173471747.pdf ZRSKP_Zubac_173471747.pdf 1 48BB82B90006AC6869B25573482105A8 b0fc0ebc1de416be347a0e4b8d8bc7b891b83c0ddf39cddfed5212921c949b7e 1e4d4d31-89ff-11ee-9ccb-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23560 https://www.nature.com/articles/s41598-023-46177-x 0 a4c62311-89fe-11ee-9ccb-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=23558 Znanstveno-raziskovalno središče Koper / Centro di Ricerche Scientifiche Capodistria 0 0 0