| Title: | Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease |
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| Authors: | Kačar, Mark (Author)
Fitton, John (Author)
Gough, Andrew K (Author)
Buch, Maya H (Author)
McGonagle, Dennis (Author)
Savic, Sinisa (Author) |
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| Language: | English |
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| Tipology: | 1.01 - Original Scientific Article |
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| Organisation: |  UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik |
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| Abstract: | This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use. |
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| Keywords: | adult onset Still's disease -- drug therapy, ankylosing spondylitis, arthritis, antirheumatic agents, undifferentiated systemic autoinflammatory disease, disease-modifying antirheumatic drugs |
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| Year of publishing: | 2020 |
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| Publisher: | BMJ Publishing |
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| Source: | Velika Britanija |
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| COBISS_ID: | 58397187  |
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| UDC: | 616-002 |
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| ISSN on article: | 2056-5933 |
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| DOI: | 10.1136/ rmdopen-2020-001246 |
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| Note: | Nasl. z nasl. zaslona;
Opis vira z dne 6. 4. 2021;
Št. članka: e001246;
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| Views: | 667 |
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| Downloads: | 399 |
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| Files: |  PDF - Presentation file, download (321,22 KB)
 URL - Source URL, visit https://rmdopen.bmj.com/content/rmdopen/6/2/e001246.full.pdf
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| | | Journal: | RMD open
BMJ
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| | | Metadata: |     |
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| Rights: | © Author(s) (or their employer(s)) 2020. |
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