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Title:Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease
Authors:ID Kačar, Mark, Klinika Golnik (Author)
ID Fitton, John (Author)
ID Gough, Andrew K (Author)
ID Buch, Maya H (Author)
ID McGonagle, Dennis (Author)
ID Savic, Sinisa (Author)
Files:.pdf PDF - Presentation file, download (321,22 KB)
MD5: 0EA382F8C02ADAF3AF616620A6889371
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Typology:1.01 - Original Scientific Article
Organization:Logo UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
Abstract:This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use.
Keywords:adult onset Still's disease -- drug therapy, ankylosing spondylitis, arthritis, antirheumatic agents, undifferentiated systemic autoinflammatory disease, disease-modifying antirheumatic drugs
Publication status:Published
Publication version:Version of Record
Place of publishing:Velika Britanija
Publisher:BMJ Publishing
Year of publishing:2020
Number of pages:str. 1-5
Numbering:Vol. 6, iss. 2
PID:20.500.12556/DiRROS-13872 New window
ISSN on article:2056-5933
DOI:10.1136/ rmdopen-2020-001246 New window
COBISS.SI-ID:58397187 New window
Copyright:© Author(s) (or their employer(s)) 2020.
Note:Nasl. z nasl. zaslona; Opis vira z dne 6. 4. 2021; Št. članka: e001246;
Publication date in DiRROS:08.04.2021
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Title:RMD open
COBISS.SI-ID:32418009 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.06.2020

Secondary language

Keywords:Stillova bolezen s pričetkom v odrasli dobi -- zdravljenje z zdravili, ankilozirajoči spondilitis, artritis, antirevmatična sredstva, nediferencirana sistemska avtovnetna bolezen, imunomodulirajoči antirevmatiki