20.500.12556/DiRROS-13872 Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use. adult onset Still's disease -- drug therapy ankylosing spondylitis arthritis antirheumatic agents undifferentiated systemic autoinflammatory disease disease-modifying antirheumatic drugs Stillova bolezen s pričetkom v odrasli dobi -- zdravljenje z zdravili ankilozirajoči spondilitis artritis antirevmatična sredstva nediferencirana sistemska avtovnetna bolezen imunomodulirajoči antirevmatiki true false true BMJ Publishing Angleški jezik Ni določen © Author(s) (or their employer(s)) 2020. Neznano 2021-04-08 14:38:02 2021-04-08 14:38:02 2022-08-19 03:37:18 0000-00-00 00:00:00 2020 0 Velika Britanija 0 Nasl. z nasl. zaslona; Opis vira z dne 6. 4. 2021; Št. članka: e001246; str. 1-5 iss. 2 Vol. 6 Jul. 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-002 2056-5933 10.1136/ rmdopen-2020-001246 58397187 RAZ_Kacar_Mark_i2020.pdf RAZ_Kacar_Mark_i2020.pdf 1 0EA382F8C02ADAF3AF616620A6889371 4c6ef58d0809d7d272e648569edb9a5d237dfb2dab8c886925b7c54758d1c6a8 839abf99-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17137 https://rmdopen.bmj.com/content/rmdopen/6/2/e001246.full.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=16983 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0