Title: | Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease |
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Authors: | ID Kačar, Mark, Klinika Golnik (Author) ID Fitton, John (Author) ID Gough, Andrew K (Author) ID Buch, Maya H (Author) ID McGonagle, Dennis (Author) ID Savic, Sinisa (Author) |
Files: | PDF - Presentation file, download (321,22 KB) MD5: 0EA382F8C02ADAF3AF616620A6889371
URL - Source URL, visit https://rmdopen.bmj.com/content/rmdopen/6/2/e001246.full.pdf
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Language: | English |
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Typology: | 1.01 - Original Scientific Article |
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Organization: | UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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Abstract: | This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. All patients suffered from disease nonresponsive to conventional Disease-modifying antirheumatic drugs (DMARDs) as well as biological therapies including interleukin (IL)-1 and IL-6 blockade, relying instead on high daily doses of prednisolone. We also report the first case of Pneumocystis jirovecii infection following baricitinib use. |
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Keywords: | adult onset Still's disease -- drug therapy, ankylosing spondylitis, arthritis, antirheumatic agents, undifferentiated systemic autoinflammatory disease, disease-modifying antirheumatic drugs |
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Publication status: | Published |
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Publication version: | Version of Record |
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Place of publishing: | Velika Britanija |
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Publisher: | BMJ Publishing |
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Year of publishing: | 2020 |
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Number of pages: | str. 1-5 |
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Numbering: | Vol. 6, iss. 2 |
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PID: | 20.500.12556/DiRROS-13872 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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UDC: | 616-002 |
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ISSN on article: | 2056-5933 |
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DOI: | 10.1136/ rmdopen-2020-001246 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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COBISS.SI-ID: | 58397187 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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Copyright: | © Author(s) (or their employer(s)) 2020. |
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Note: | Nasl. z nasl. zaslona;
Opis vira z dne 6. 4. 2021;
Št. članka: e001246;
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Publication date in DiRROS: | 08.04.2021 |
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Views: | 1499 |
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Downloads: | 913 |
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Metadata: | ![Export as DC-RDF DC-RDF](teme/dirros/img/icon_dc_rdf.gif) |
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