| Naslov: | Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : final analysis of the GioTag study |
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| Avtorji: | Hochmair, Maximilian J (Avtor)
Morabito, Alessandro (Avtor)
Hao, Desiree (Avtor)
Yang, Cheng-Ta (Avtor)
Soo, Ross A (Avtor)
Yang, James C-H (Avtor)
Gucalp, Rasim (Avtor)
Halmos, Balazs (Avtor)
Märten, Angela (Avtor)
Čufer, Tanja (Avtor) |
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik |
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| Povzetek: | Aim: Final overall survival (OS) and time on treatment analysis of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) who received sequential afatinib and osimertinib. Patients & methods: Patients (n = 203) had T790M-positive disease following first-line afatinib and started osimertinib treatment >/=10 months before data entry. Primary outcome was time on treatment; OS analysis was exploratory. Results: Median time on treatment with afatinib and osimertinib was 27.7 months (90% CI: 26.7-29.9). Median OS was 37.6 months (90% CI: 35.5-41.3); median OS was 41.6 and 44.8 months in Del19-positive patients and Asian patients, respectively. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib was associated with encouraging outcomes in patients with EGFR mutation-positive NSCLC, especially in Del19-positive patients and Asian patients. |
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| Ključne besede: | non-small cell lung carcinoma -- therapy, drug therapy, afatinib, osimertinib, GioTag study |
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| Leto izida: | 2020 |
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| Založnik: | Future Medicine Ltd |
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| Izvor: | Velika Britanija |
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| UDK: | 616-006 |
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| ISSN pri članku: | 1744-8301 |
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| OceCobissID: | 521824025  |
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| COBISS_ID: | 37424899 |
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| DOI: | 10.2217/fon-2020-0740 |
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| Opombe: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 11. 2020;
Soavtorica iz Slovenije: Tanja Cufer;
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| Število ogledov: | 811 |
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| Število prenosov: | 574 |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,58 MB)
PDF - Priloga, prenos (1,10 MB)
 URL - Izvorni URL, za dostop obiščite https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0740
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| | | Nadgradivo: | Future oncology
Future Medicine
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| | | Metapodatki: |     |
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| Avtorske pravice: | © 2020 Maximilian J. Hochmair and other authors |
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