Naslov: | Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : final analysis of the GioTag study |
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Avtorji: | Hochmair, Maximilian J (Avtor) Morabito, Alessandro (Avtor) Hao, Desiree (Avtor) Yang, Cheng-Ta (Avtor) Soo, Ross A (Avtor) Yang, James C-H (Avtor) Gucalp, Rasim (Avtor) Halmos, Balazs (Avtor) Märten, Angela (Avtor) Čufer, Tanja (Avtor) |
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Jezik: | Angleški jezik |
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Tipologija: | 1.01 - Izvirni znanstveni članek |
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Organizacija: | UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik |
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Povzetek: | Aim: Final overall survival (OS) and time on treatment analysis of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) who received sequential afatinib and osimertinib. Patients & methods: Patients (n = 203) had T790M-positive disease following first-line afatinib and started osimertinib treatment >/=10 months before data entry. Primary outcome was time on treatment; OS analysis was exploratory. Results: Median time on treatment with afatinib and osimertinib was 27.7 months (90% CI: 26.7-29.9). Median OS was 37.6 months (90% CI: 35.5-41.3); median OS was 41.6 and 44.8 months in Del19-positive patients and Asian patients, respectively. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib was associated with encouraging outcomes in patients with EGFR mutation-positive NSCLC, especially in Del19-positive patients and Asian patients. |
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Ključne besede: | non-small cell lung carcinoma -- therapy, drug therapy, afatinib, osimertinib, GioTag study |
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Leto izida: | 2020 |
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Založnik: | Future Medicine Ltd |
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Izvor: | Velika Britanija |
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UDK: | 616-006 |
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ISSN pri članku: | 1744-8301 |
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OceCobissID: | 521824025  |
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COBISS_ID: | 37424899  |
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DOI: | 10.2217/fon-2020-0740  |
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Opombe: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 11. 2020;
Soavtorica iz Slovenije: Tanja Cufer;
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Število ogledov: | 811 |
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Število prenosov: | 574 |
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Datoteke: | PDF - Predstavitvena datoteka, prenos (1,58 MB)
PDF - Priloga, prenos (1,10 MB)
URL - Izvorni URL, za dostop obiščite https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0740
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| Nadgradivo: | Future oncology Future Medicine
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| Metapodatki: |  |
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Avtorske pravice: | © 2020 Maximilian J. Hochmair and other authors |
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