Title: | Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : final analysis of the GioTag study |
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Authors: | ID Hochmair, Maximilian J (Author) ID Morabito, Alessandro (Author) ID Hao, Desiree (Author) ID Yang, Cheng-Ta (Author) ID Soo, Ross A (Author) ID Yang, James C-H (Author) ID Gucalp, Rasim (Author) ID Halmos, Balazs (Author) ID Märten, Angela (Author) ID Čufer, Tanja, Klinika Golnik, Medicinska fakulteta UL (Author) |
Files: | PDF - Presentation file, download (1,58 MB) MD5: E5B817D1334C093553F6EC429C0A7178
PDF - Supplement, download (1,10 MB) MD5: C384BC86E3FD51111A4BAD50BC370759
URL - Source URL, visit https://www.futuremedicine.com/doi/pdf/10.2217/fon-2020-0740
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Language: | English |
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Typology: | 1.01 - Original Scientific Article |
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Organization: | UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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Abstract: | Aim: Final overall survival (OS) and time on treatment analysis of patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC) who received sequential afatinib and osimertinib. Patients & methods: Patients (n = 203) had T790M-positive disease following first-line afatinib and started osimertinib treatment >/=10 months before data entry. Primary outcome was time on treatment; OS analysis was exploratory. Results: Median time on treatment with afatinib and osimertinib was 27.7 months (90% CI: 26.7-29.9). Median OS was 37.6 months (90% CI: 35.5-41.3); median OS was 41.6 and 44.8 months in Del19-positive patients and Asian patients, respectively. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib was associated with encouraging outcomes in patients with EGFR mutation-positive NSCLC, especially in Del19-positive patients and Asian patients. |
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Keywords: | non-small cell lung carcinoma -- therapy, drug therapy, afatinib, osimertinib, GioTag study |
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Publication status: | In print |
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Publication version: | Version of Record |
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Place of publishing: | Velika Britanija |
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Publisher: | Future Medicine Ltd |
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Year of publishing: | 2020 |
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Number of pages: | str. [1-10] |
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Numbering: | Vol. 16, no. |
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PID: | 20.500.12556/DiRROS-12685 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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UDC: | 616-006 |
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ISSN on article: | 1744-8301 |
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DOI: | 10.2217/fon-2020-0740 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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COBISS.SI-ID: | 37424899 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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Copyright: | © 2020 Maximilian J. Hochmair and other authors |
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Note: | Nasl. z nasl. zaslona;
Opis vira z dne 14. 11. 2020;
Soavtorica iz Slovenije: Tanja Cufer;
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Publication date in DiRROS: | 18.11.2020 |
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Views: | 1668 |
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Downloads: | 1356 |
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Metadata: | ![Export as DC-RDF DC-RDF](teme/dirros/img/icon_dc_rdf.gif) |
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