| Naslov: | Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : updated analysis of the observational GioTag study |
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| Avtorji: | Hochmair, Maximilian J (Avtor)
Morabito, Alessandro (Avtor)
Hao, Desiree (Avtor)
Yang, Cheng-Ta (Avtor)
Soo, Ross A (Avtor)
Yang, James C-H (Avtor)
Gucalp, Rasim (Avtor)
Halmos, Balazs (Avtor)
Wang, Lara (Avtor)
Märten, Angela (Avtor)
Čufer, Tanja (Avtor) |
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik |
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| Povzetek: | Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. |
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| Ključne besede: | non-small cell lung carcinoma - therapy, drug therapy, afatinib, osimertinib, GioTag study |
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| Leto izida: | 2019 |
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| Založnik: | Future Medicine Ltd |
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| Izvor: | Velika Britanija |
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| UDK: | 616.2 |
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| ISSN pri članku: | 1744-8301 |
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| OceCobissID: | 521824025  |
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| COBISS_ID: | 2048610929 |
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| DOI: | 10.2217/fon-2019-0346 |
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| Opombe: | Nasl. z nasl. zaslona;
Soavtorica iz Slovenije: Tanja Cufer;
Opis vira z dne 10. 1. 2020;
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| Število ogledov: | 834 |
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| Število prenosov: | 491 |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,58 MB)
PDF - Priloga, prenos (1,10 MB)
 URL - Izvorni URL, za dostop obiščite https://www.futuremedicine.com/doi/full/10.2217/fon-2019-0346
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| | | Nadgradivo: | Future oncology
Future Medicine
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| | | Metapodatki: |     |
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| Avtorske pravice: | © 2019 Maximilian J Hochmair |
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