Title: | Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : updated analysis of the observational GioTag study |
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Authors: | ID Hochmair, Maximilian J (Author) ID Morabito, Alessandro (Author) ID Hao, Desiree (Author) ID Yang, Cheng-Ta (Author) ID Soo, Ross A (Author) ID Yang, James C-H (Author) ID Gucalp, Rasim (Author) ID Halmos, Balazs (Author) ID Wang, Lara (Author) ID Märten, Angela (Author) ID Čufer, Tanja, Klinika Golnik, Medicinska fakulteta UL (Author) |
Files: | PDF - Presentation file, download (1,58 MB) MD5: AE826F62EC54CB83F71667FE803EEB71
PDF - Supplement, download (1,10 MB) MD5: 501E9A968487DEB2D03082EAB847B278
URL - Source URL, visit https://www.futuremedicine.com/doi/full/10.2217/fon-2019-0346
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Language: | English |
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Typology: | 1.01 - Original Scientific Article |
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Organization: | UKPBAG - University Clinic of Respiratory and Allergic Diseases Golnik
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Abstract: | Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. |
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Keywords: | non-small cell lung carcinoma - therapy, drug therapy, afatinib, osimertinib, GioTag study |
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Publication status: | Published |
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Publication version: | Version of Record |
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Place of publishing: | Velika Britanija |
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Publisher: | Future Medicine Ltd |
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Year of publishing: | 2019 |
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Number of pages: | str. 2905-2914 |
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Numbering: | Vol. 15, iss. 25 |
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PID: | 20.500.12556/DiRROS-12417 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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UDC: | 616.2 |
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ISSN on article: | 1744-8301 |
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DOI: | 10.2217/fon-2019-0346 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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COBISS.SI-ID: | 2048610929 ![Link is opened in a new window New window](teme/dirros/img/NovoOkno.png) |
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Copyright: | © 2019 Maximilian J Hochmair |
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Note: | Nasl. z nasl. zaslona;
Soavtorica iz Slovenije: Tanja Cufer;
Opis vira z dne 10. 1. 2020;
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Publication date in DiRROS: | 11.09.2020 |
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Views: | 1616 |
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Downloads: | 1202 |
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Metadata: | ![Export as DC-RDF DC-RDF](teme/dirros/img/icon_dc_rdf.gif) |
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