Digitalni repozitorij raziskovalnih organizacij Slovenije

Izpis gradiva
A+ | A- | SLO | ENG

Naslov:Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation
Avtorji:Zimmermann, Matthias (Avtor)
Traxler, Denise (Avtor)
Bekos, Christine (Avtor)
Simader, Elisabeth (Avtor)
Mueller, Thomas (Avtor)
Graf, Alexandra (Avtor)
Lainščak, Mitja (Avtor)
Marčun, Robert (Avtor)
Košnik, Mitja (Avtor)
Fležar, Matjaž (Avtor)
Rozman, Aleš (Avtor)
Korošec, Peter (Avtor)
Jezik:Angleški jezik
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:Logo UKPBAG - Univerzitetna klinika za pljučne bolezni in alergijo Golnik
Povzetek:Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
Ključne besede:COPD, acute exacerbation, disease activity
Leto izida:2020
Založnik:Springer
Izvor:ZDA
UDK:616.2
ISSN pri članku:1466-1268
OceCobissID:515403545 Povezava se odpre v novem oknu
COBISS_ID:2048610673 Povezava se odpre v novem oknu
DOI:10.1007/s12192-019-01057-0 Povezava se odpre v novem oknu
Opombe:Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Mitja Lainscak, Robert Marčun, Mitja Košnik, Matjaž Fležar, Aleš Rozman, Peter Korošec; Opis vira z dne 8. 1. 2020;
Število ogledov:749
Število prenosov:349
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (679,90 KB)
URL URL - Izvorni URL, za dostop obiščite https://link.springer.com/content/pdf/10.1007/s12192-019-01057-0.pdf
 
Nadgradivo:Cell stress chaperones
Churchill Livingstone
 
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Avtorske pravice:The Author(s) 2019
:
  
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.


Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:29.07.2020

Nazaj