20.500.12556/DiRROS-12278 Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients. COPD acute exacerbation disease activity KOPB akutno poslabšanje aktivnost bolezni true false true Springer Angleški jezik Ni določen The Author(s) 2019 Neznano 2020-07-29 12:55:28 2020-07-29 12:55:28 2022-08-18 03:36:23 0000-00-00 00:00:00 2020 0 ZDA 0 Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Mitja Lainscak, Robert Marčun, Mitja Košnik, Matjaž Fležar, Aleš Rozman, Peter Korošec; Opis vira z dne 8. 1. 2020; str. 141-149 iss. Vol. 25 2020 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 1466-1268 10.1007/s12192-019-01057-0 2048610673 515403545 RAZ_Zimmermann_Matthias_i2020.pdf RAZ_Zimmermann_Matthias_i2020.pdf 1 91BE12F2ECA3189122E6B975B59E547F 571a805baab8fff339220652d0073e45a5ef1fb333747333d8382989f710c45d 8ea1aaf6-17b6-11ed-b6b8-001a4af901a5 https://dirros.openscience.si/Dokument.php?lang=slv&id=17325 https://link.springer.com/content/pdf/10.1007/s12192-019-01057-0.pdf 1 https://dirros.openscience.si/Dokument.php?lang=slv&id=14776 Univerzitetna klinika za pljučne bolezni in alergijo Golnik 0 0 0