Iskanje po repozitoriju

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Povzetek: Primary and secondary mineral resources are of strategic importance to the EU economy. Montenegro, as a country candidate for membership in the EU, is required to follow (and later to implement) European policies, strategies as well as initiatives, including those related to mineral resources and the mining sector. The importance of providing access to mineral raw materials in the future is recognized by the EU, as well as meeting the needs of European industry, maintaining employment and ensuring further development. Considering the overall economic situation in Montenegro, it is important to encourge the mining sector and other industries based on the use of mineral resources in making a greater contribution to the development and sustainability of society as a whole and also increase the share of national GDP. The potential for discovery and utilization of primary and secondary mineral resources in Montenegro is demonstrated. The most important metallic mineral resources are bauxite, lead and zinc, while conventional energy resources include coal (oil and gas potential has yet to be proven). In addition, there are abundant non-metallic mineral raw materials - industrial minerals and construction materials. Secondary mineral resources, especially aluminous red mud (bauxite residue), are also significant and have been the subject of research in recent years. Tailings from flotation processes at operating and abandoned lead and zinc mines might also be of interest for metal recovery. Bottom and flay ash from thermal power plants, slag from steel production, as well as marlstone and limestone from the hanging wall of coal deposits may also have potential. Waste rocks could be used particularly for secondary aggregate production. A database was developed and the most important deposits of primary and secondary mineral resources in Montenegro were mapped during the RESEERVE project. Mineral data were harmonised so as to be INSPIRE compliant. In addition, some novel geochemical exploration results of secondary mineral resources are presented.
Ključne besede: primary and secondary mineral resources, Montenegro, RESEERVE project, European geological data platform (EGDI), INSPIRE
Objavljeno v DiRROS: 16.11.2022; Ogledov: 427; Prenosov: 169
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Objavljeno v DiRROS: 02.11.2022; Ogledov: 662; Prenosov: 357
Celotno besedilo (7,28 MB)
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Povzetek: The low-grade metasedimentary rocks of Medvednica Mt. (Northwest Croatia) are associated with ortho-greenschists (metabasalts). The Lower to Upper Triassic age of the protolith of the low-grade metamorphic rocks belonging to the Stari Potok, Adolfovac, Tusti Breg, Bliznec, Mrzljak, and Sljeme lithostratigraphic units is determined on the basis of conodonts and field relationships. The metamorphic age of the Triassic metasedimentary rocks from the Risnjak lithostratigraphic units is assumed to be Jurassic. Petrographic and geochemical analyses of ortho-greenschists point to a tholeiite basic magmatic protolith rock having T-MORB (transitional midocean-ridge basalt) characteristics. The ortho-greenschists of the Sljeme lithostratigraphic unit underwent retrograde metamorphism and show metamorphic zoning from the epidote–amphibolite facies to the lower parts of the greenschist facies. However, the greenschists of the Tusti Breg and Bliznec units are characterized by prograde metamorphism ranging from lower to higher greenschist facies. This metamorphism is associated with Jurassic subduction (165–150 Ma) and closure of the Western Tethys. Retrograde metamorphism took place during the collision of the Adriatic and Eurasian plates in the Lower Cretaceous (125–110 Ma).
Ključne besede: Mt. Medvednica, greenschists, prograde–retrograde metamorphism, T-MORB, subduction–collision, Western Tethys
Objavljeno v DiRROS: 25.07.2022; Ogledov: 474; Prenosov: 178
Celotno besedilo (9,87 MB)

Objavljeno v DiRROS: 22.03.2022; Ogledov: 642; Prenosov: 406
Celotno besedilo (3,94 MB)
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Povzetek: Background. Immunotherapy with immune checkpoint inhibitors (ICIs) recently became the standard treatment for patients with advanced non-small cell lung cancer (NSCLC). Here, we present the first results of a real-world observational study on the effectiveness of ICI monotherapy in patients with advanced NSCLC treated at a single academic center in a Central and Eastern European (CEE) country. Materials and methods. Overall, 66 consecutive patients with advanced NSCLC treated with ICIs in everyday clinical practice, either with first-line pembrolizumab (26 patients) or second-line atezolizumab, nivolumab, or pembrolizumab (40 patients), from August 2015 to November 2018, were included. All data were retrieved from a hospital lung cancer registry, in which the data is collected prospectively. Results. Included patients had a median age of 64 years, most were male (55%), 6% were in performance status >/=2, and 18% had controlled central nervous system metastases at baseline. In first-line, the median progression-free survival (mPFS) was 9.3 months, while the median overall survival (mOS) was not reached. The 1-year overall survival (OS) was 62%. In second-line, the mPFS and mOS were 3.5 months and 9.9 months, respectively, with a 1-year OS of 35%. In the overall population, adverse events of any grade were recorded in 79% of patients and of severe grade (3-4) in 12% of patients. Conclusion. The first real-world outcomes of NSCLC immunotherapy from a CEE country suggest comparable effectiveness to those observed in clinical trials and other real-world series, mainly coming from North America and Western European countries. Further data to inform on the real-world effectiveness of immunotherapy worldwide are needed.
Ključne besede: non-small cell lung carcinoma, immunotherapy, advanced non-small cell lung cancer, real-world data, Europe, Central Europe, Eastern Europe
Objavljeno v DiRROS: 15.12.2021; Ogledov: 826; Prenosov: 429
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