161. Genomics and adaptation in forest ecosystemsCharalambos Neophytou, Katrin Heer, Pascal Miles, Martina Peter, Tanja Pyhäjärvi, Marjana Westergren, Christian Rellstab, Felix Gugerli, 2022, izvirni znanstveni članek Povzetek: Rapid human-induced environmental changes like climate warming represent a challenge for forest ecosystems. Due to their biological complexity and the long generation time of their keystone tree species, genetic adaptation in these ecosystems might not be fast enough to keep track with conditions changing at such a fast pace. The study of adaptation to environmental change and its genetic mechanisms is therefore key for ensuring a sustainable support and management of forests. The 4-day conference of the European Research Group EvolTree (https://www.evoltree.eu) on the topic of “Genomics and Adaptation in Forest Ecosystems” brought together over 130 scientists to present and discuss the latest developments and findings in forest evolutionary research. Genomic studies in forest trees have long been hampered by the lack of high-quality genomics resources and affordable genotyping methods. This has dramatically changed in the last few years; the conference impressively showed how such tools are now being applied to study past demography, adaptation and interactions with associated organisms. Moreover, genomic studies are now finally also entering the world of conservation and forest management, for example by measuring the value or cost of interspecific hybridization and introgression, assessing the vulnerability of species and populations to future change, or accurately delineating evolutionary significant units. The newly launched conference series of EvolTree will hopefully play a key role in the exchange and synthesis of such important investigations.
Ključne besede: gene conservation, genetic diversity, local adaptation, pathogens, selection, mycorrhizal fungi
Objavljeno v DiRROS: 18.02.2022; Ogledov: 677; Prenosov: 498
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162. Utility of telomerase gene mutation testing in patients with idiopathic pulmonary fibrosis in routine practiceJulij Šelb, Katarina Osolnik, Izidor Kern, Peter Korošec, Matija Rijavec, 2022, izvirni znanstveni članek Povzetek: Recent studies have suggested that causative variants in telomerase complex genes (TCGs) are present in around 10% of individuals with idiopathic pulmonary fibrosis (IPF) regardless of family history of the disease. However, the studies used a case-control rare variant enrichment study design which is not directly translatable to routine practice. To validate the prevalence results and to establish the individual level, routine clinical practice, and utility of those results we performed next generation sequencing of TCGs on a cohort of well-characterized consecutive individuals with IPF (diagnosis established according to ATS/ERS/JRS/ALAT guidelines). Of 27 IPF patients, three had a family history of idiopathic interstitial pneumonia (familial IPF) and 24 did not (sporadic IPF). Pathogenic/likely-pathogenic variants (according to American College of Medical Genetics criteria) in TCG were found in three individuals (11.1%) of the whole cohort; specifically, they were present in 2 out of 24 (8.3%) of the sporadic and in 1 out of 3 (33.3%) of the patients with familial IPF. Our results, which were established on an individual-patient level study design and in routine clinical practice (as opposed to the case-control study design), are roughly in line with the around 10% prevalence of causative TCG variants in patients with IPF.
Ključne besede: telomerase, idiopathic pulmonary fibrosis, genetic variation, telomerase complex
Objavljeno v DiRROS: 07.02.2022; Ogledov: 824; Prenosov: 375
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163. Heterogeneous response of airway eosinophilia to anti-IL-5 biologics in severe asthma patientsMaruša Kopač, Matija Rijavec, Peter Korošec, Urška Bidovec, Izidor Kern, Romana Vantur, Sabina Škrgat, 2022, izvirni znanstveni članek Povzetek: Many questions concerning responders (R) and nonresponders (NR) in severe eosinophilic asthma (SEA) after blocking the IL-5 (interleukin 5) pathway are still not clear, especially regarding the early parameters of response to biologics in personalized treatment strategies. We evaluated 17 SEA patients treated with anti-IL-5 biologics (16 patients mepolizumab, one patient benralizumab) before the introduction of biologics, and at a week 16 follow-up. Clinical, cellular and immunological parameters in peripheral blood were measured in R and NR. Sputum induction with the measurement of cellular and immunological parameters was performed at 16 weeks only. There were 12 R and 5 NR to biologics. After 16 weeks, there was a significant improvement in percentages of FEV1 (p = 0.001), and asthma control test (ACT) (p = 0.001) in the R group, but not in NR. After 16 weeks, the eosinophils in induced sputum were 27.0% in NR and 4.5% in R (p = 0.05), with no difference in IL-5 concentrations (p = 0.743). Peripheral eosinophilia decreased significantly in NR (p = 0.032) and R (p = 0.002). In patients with SEA on anti-IL-5 therapy, there was a marked difference in airway eosinophilic inflammation between R and NR already at 16 weeks, after anti-IL-5 introduction.
Objavljeno v DiRROS: 13.01.2022; Ogledov: 993; Prenosov: 563
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164. Energetska storitev : energetsko pogodbeništvo : toplota namesto energentaNike Krajnc, Thomas Loibnegger, Peter Prislan, Marjan Dolenšek, Christian Metschina, 2014, strokovna monografija Ključne besede: energetika, učinkovita raba energije, varčevanje z energijo, lesna biomasa, ekonomika
Objavljeno v DiRROS: 05.01.2022; Ogledov: 942; Prenosov: 294
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165. Kakovostna lesna goriva za vsakogar : koristne informacije za vse, ki se ogrevajo z lesomNike Krajnc, Mitja Piškur, Peter Prislan, Matevž Triplat, 2014, strokovna monografija Ključne besede: energetski viri, ogrevanje, drva, lesni sekanci, lesni peleti
Objavljeno v DiRROS: 05.01.2022; Ogledov: 1079; Prenosov: 341
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166. Stanje žagarske panoge v Sloveniji v letu 2019Špela Ščap, Nike Krajnc, Peter Prislan, 2021, izvirni znanstveni članek Povzetek: Z raziskavo, opravljeno v letu 2020, smo želeli ugotoviti stanje žagarske panoge v Sloveniji v letu 2019 (t.j. ocena števila obratov, ocena razžagane količine lesa, uporaba ostankov in vpliv pandemije covid-19 na poslovanje). Pred izvedbo raziskave smo iz različnih podatkovnih baz zbrali seznam 1.128 poslovnih subjektov, ki imajo kot C16 (Obdelava in predelava lesa) registrirano primarno ali sekundarno dejavnost. Izpolnjene vprašalnike nam je posredovalo 588 podjetij, od katerih se jih 328 ukvarja z razžagovanjem hlodovine. V letu 2019 je skupna evidentirana količina razžagane hlodovine znašala 1,71 milijona m3, od tega so z 84 % prevladovali iglavci. Žagarski obrati, ki so sodelovali v anketi, so v letu 2019 proizvedli 633.894 m3 žaganega lesa. Proizvodnja žagovine in lesnega prahu je znašala 237.389 ton, kosovnih ostankov pa 252.655 m3. Epidemija nalezljive bolezni covid-19 in ukrepi za njeno zajezitev so v obdobju od marca do maja 2020 (prvi val) vplivali na poslovanje podjetij v primarni lesnopredelovalni industriji; 63 % sodelujočih podjetij v tem sklopu vprašanj je občutilo posledice epidemije.
Ključne besede: žagarstvo, žagan les, žagarski obrat, predelava okroglega lesa, iglavci, listavci
Objavljeno v DiRROS: 18.12.2021; Ogledov: 1179; Prenosov: 348
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168. Mnenje za spremljanje bolnikov po preboleli covidni pljučniciMatjaž Turel, Natalija Edelbaher, Matjaž Fležar, Matevž Harlander, Peter Kecelj, Izidor Kern, Majda Kočar, Peter Kopač, Mitja Košnik, Robert Marčun, Igor Požek, Mirjana Rajer, Irena Šarc, Jurij Šorli, Dušanka Vidovič, Katarina Osolnik, 2021, izvirni znanstveni članek Povzetek: Pljučnica je najpogostejši vzrok za težji potek okužbe z virusom SARS-CoV-2 in s hospitalizacijo. Potek covidne pljučnice je lahko različen; infiltrati, vidni na rentgenski sliki, se lahko resorbirajo spontano, včasih pa je potrebno zdravljenje s sistem-skimi glukokortikoidi. Ob odpustu iz bolnišnice zdravljenje običajno še ni končano, zato je Združenje pulmologov Slovenije v želji po enotnem obravnavanju bolnikov s covidno pljučnico izdelalo mnenje za obravnavo in sledenje bolnikov po od-pustu iz bolnišnice. Zavedamo se, da ob novi bolezni ne gre za dokončno priporočilo, saj bodo nova spoznanja o covidni pljučnici zanesljivo zahtevala obnavljanje priporočil.
Ključne besede: covid-19, mnenja, pljučnica, pulmologija, sistemski glukokortikoidi, covidna pljučnica
Objavljeno v DiRROS: 15.12.2021; Ogledov: 1138; Prenosov: 210
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170. Priročnik za določanje korenin olesenelih rastlinTanja Mrak, Jožica Gričar, Peter Železnik, Hojka Kraigher, 2016, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: določevalni ključi, znanstvene monografije, morfologija rastlin, anatomija rastlin, drobne korenine, EUFORINNO
Objavljeno v DiRROS: 03.11.2021; Ogledov: 758; Prenosov: 0 |
