1. Geographical and temporal diversity of ‘Candidatus Phytoplasma solani' in wine-growing regions in Slovenia and AustriaNataša Mehle, Sanda Kavčič, Sara Mermal, Sara Vidmar, Maruša Pompe Novak, Monika Riedle-Bauer, Günter Brader, Aleš Kladnik, Marina Dermastia, 2022, izvirni znanstveni članek Povzetek: As the causal agent of the grapevine yellows disease Bois noir, ‘Candidatus Phytoplasma solani’ has a major economic impact on grapevines. To improve the control of Bois noir, it is critical to understand the very complex epidemiological cycles that involve the multiple “Ca. P. solani” host plants and insect vectors, of which Hyalesthes obsoletus is the most important. In the present study, multiple genotyping of the tuf, secY, stamp, and vmp1 genes was performed. This involved archived grapevine samples that were collected during an official survey of grapevine yellows throughout the wine-growing regions of Slovenia (from 2003 to 2016), plus samples from Austrian grapevines, stinging nettle, field bindweed, and insect samples (collected from 2012 to 2019). The data show that the tuf-b2 type of the tuf gene has been present in eastern Slovenia since at least 2003. The hypotheses that the occurrence of the haplotypes varies due to the geographical position of Slovenia on the Italian–Slovenian Karst divide and that the haplotypes are similar between Slovenian and Austrian Styria were confirmed. The data also show haplotype changes for host plants and H. obsoletus associated with ‘Ca. P. solani,’ which might be linked to new epidemiological cycles of this phytoplasma that involve not just new plant sources and new insect vectors, but also climate and land-use changes.
Ključne besede: Bois noir, genotyping, ‘Ca. P. solani’, tuf gene, secY, survey, tuf-b2, stamp
Objavljeno v DiRROS: 10.06.2022; Ogledov: 108; Prenosov: 81
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6. Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumoursBarbara Breznik, Helena Motaln, Tamara Lah Turnšek, pregledni znanstveni članek Povzetek: Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer.
Ključne besede: cellular cross-talk, glioblastoma, invasion, mesenchymal stem cells, protease-cytokine signalling
Objavljeno v DiRROS: 08.09.2017; Ogledov: 3116; Prenosov: 1007
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9. Elemental composition of wheat, common buckwheat, and tartary buckwheat grains under conventional productionLea Orožen, Katarina Vogel-Mikuš, Matevž Likar, Marijan Nečemer, Peter Kump, Marjana Regvar, 2012, izvirni znanstveni članek Ključne besede: dietary reference intake, energy dispersive X-ray fluorescence spectrometry, metals, minerals, trace elements, total reflection X-ray fluorescence spectrometry
Objavljeno v DiRROS: 11.07.2017; Ogledov: 3199; Prenosov: 948
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