Iskanje po repozitoriju

A+ | A- | | SLO | ENG

Povzetek: Background: Myocardial damage in myocarditis is assessed through late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR). Variability in quantifying myocarditis extent results from imprecise image segmentation and inconclusive data on quantification method selection. To improve analysis precision, segmentation steps are systematically ranked based on their inherent risks of error. Additionally, data on two distinct quantification methods are presented. Methods: Using newly developed software, four experts analyzed five LGE-CMR left ventricular (LV) short-axis (SAx) images of myocarditis patients in three sessions. Regions of interest (ROIs) (myocardial (ROImyoc), reference (ROIref), and exclusion region (ROIexcl)) were identified and used to calculate LGE extent with 3σ (intensity above three standard deviations (σ) in reference) and the full width at half maximum (FWHM) method (intensity above 50% of maximum signal in reference). The reference LGE extent was calculated and the influence of the ROIs on LGE extent variability was determined. Interobserver and intraobserver variability were evaluated as 1-intraclass correlation coefficient (ICC). Results: LGE extent variability was 6.2 ± 0.6% for 3σ and 4.0 ± 0.6% for FWHM. The contributions of ROImyoc, ROIref, and ROIexcl were 1.5 ± 0.2%, 2.7 ± 0.4%, and 2 ± 0.3%, respectively, for 3σ, and 1.1 ± 0.1%, 1.6 ± 0.4%, and 1.3 ± 0.3%, respectively, for FWHM. LGE extent was lower in FWHM. Interobserver variability was 0.56 for 3σ and 0.43 for FWHM. The intraobserver variability was higher for the 3σ method in all four observers. Conclusion: ROIref selection contributed most to LGE extent variability. FWHM yielded lower LGE extent and lower inter- and intraobserver variability. Due to low statistical significance, the findings are only partially confirmed.
Ključne besede: myocarditis, cardiac magnetic resonance, variability, full width at half maximum, thresholding methods, segmentation
Objavljeno v DiRROS: 03.06.2026; Ogledov: 165; Prenosov: 101
Celotno besedilo (2,14 MB)
Gradivo ima več datotek! Več...

Ključne besede: breast reconstruction, mastectomy, free flap, reconstruction methods, DIEP flap, autologous breast reconstruction, reconstruction with breast implants
Objavljeno v DiRROS: 15.05.2026; Ogledov: 193; Prenosov: 119
Celotno besedilo (1,70 MB)
Gradivo ima več datotek! Več...

Povzetek: This paper presents an adaptive hyperviscosity stabilisation procedure for the Radial Basis Function-generated Finite Difference (RBF-FD) method, aimed at solving linear and non-linear advection-dominated transport equations on domains without a boundary. The approach employs an equation independent algorithm that adaptively determines the hyperviscosity constant based on the spectral radius of the RBF-FD evolution matrix. The proposed procedure supports general node layouts and is not tailored for specific equations, avoiding the limitations of empirical tuning and von Neumann-based estimates. To reduce computational cost, it is shown that lower monomial augmentation in the approximation of the hyperviscosity operator can still ensure consistent stabilisation, enabling the use of smaller stencils and improving overall efficiency. A hybrid strategy employing different spline orders for the advection and hyperviscosity operators is also implemented to enhance stability. The method is evaluated on pure linear advection and non-linear Burgers’ equation, demonstrating stable performance with limited numerical dissipation. The two main contributions are: (1) a general hyperviscosity RBF-FD solution procedure demonstrated on both linear and non-linear advection-dominated problems, and (2) an in-depth analysis of the behaviour of hyperviscosity within the RBF-FD framework, addressing the interplay between key free parameters and their influence on numerical results.
Ključne besede: meshless methods, hyperviscosity, stabilisation scheme, advection, Burgers' equation
Objavljeno v DiRROS: 24.03.2026; Ogledov: 300; Prenosov: 185
Celotno besedilo (4,21 MB)
Gradivo ima več datotek! Več...

Povzetek: Lupins (Lupinus spp.) are climate-resistant grain legumes gaining attention as sustainable protein sources. However, their use in the human diet is limited by quinolizidine alkaloids (QAs), a class of nitrogenous secondary metabolites. QAs represent a nutritional paradox: They are central to plant defence mechanisms, yet confer toxicity and bitterness that compromise food safety and consumer acceptance. Recent findings suggest that at sub-toxic concentrations, certain QAs may exert bioactivities that could be important for metabolic regulation. Thus, the sustainable integration of lupins into food systems depends on whether QAs are considered as undesirable contaminants or redefined as bioactive phytochemicals with dose-dependent functional potential. Significant methodological progress has been made over the last five years. Advances in high-resolution techniques and metabolomics have expanded the structural catalogue of QAs, facilitated species- and genotype-specific chemotyping and allowed first conclusions on biosynthesis. At the technological level, novel processing methods have improved the efficiency of QA removal while maintaining protein quality and, in some cases, have enabled the selective extraction of alkaloids for potential valorisation. This review critically synthesises recent advances in QA chemistry, biosynthesis, analytical methodologies, toxicology, processing strategies and emerging bioactivities. Despite this progress, major challenges remain, including the lack of standardised analytical protocols, insufficiently defined sensory thresholds, fragmented regulatory frameworks and the absence of clinical validation. Future research should shift from exclusive alkaloid elimination towards controlled modulation and selective valorisation to establish lupins as safe, multifunctional crops contributing to food security, human health and sustainable agriculture.
Ključne besede: Lupinus, quinolizidine alkalois, food safety, analytical methods, detoxification, functional bioactivity
Objavljeno v DiRROS: 03.03.2026; Ogledov: 408; Prenosov: 299
Celotno besedilo (2,75 MB)
Gradivo ima več datotek! Več...

Povzetek: Honeybees and their products integrate landscape-level chemical exposure, making apicultural matrices valuable bioindicators for both food safety and environmental monitoring. This review summarizes current knowledge on pesticide residues in honey, pollen, beebread, beeswax, royal jelly, and propolis from 2019 to 2024, with an overview of analytical methodologies used in their determination. Multi-residue methods remain dominated by Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) extraction combined with liquid and gas chromatography coupled to tandem mass spectrometry, while high-resolution MS enables broader screening. Highly polar pesticides, particularly glyphosate and its metabolites, require specialised single-residue approaches, such as the Quick Polar Pesticides (QuPPe) method and ion chromatography–high-resolution mass spectrometry (IC-HRMS). Co-occurrence patterns frequently involve mixtures of neonicotinoids, acaricides, and fungicides, reflecting combined agricultural and in-hive treatments. Regarding matrices, honey typically shows insecticide and acaricide residues, pollen concentrates fungicides and insecticides as the main exposure route, and beeswax acts as a long-term sink for lipophilic compounds; royal jelly generally exhibits the lowest contamination levels. Although exceedances of Maximum Residue Limits in honey remain uncommon in European monitoring programs, the presence of pesticide mixtures and limited residue data for bee-related products beyond honey raise concern. Future research should prioritize harmonized residue limits for all beekeeping matrices, standardized quality control and reporting practices, targeted mixture-toxicity assessment under realistic co-exposure scenarios, and the broader adoption of green, miniaturized, and matrix-tailored sample preparation strategies to enhance sensitivity, sustainability, and comparability across studies.
Ključne besede: apicultural products, honey, pesticides residues, analytical methods, mass spectrometry, food safety, environmental monitoring, plant protection products
Objavljeno v DiRROS: 24.02.2026; Ogledov: 435; Prenosov: 264
Celotno besedilo (3,99 MB)
Gradivo ima več datotek! Več...