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Povzetek: This book is the seventh volume in the ECOTHEE book series, which is published every two years and was first published in the field of ecumenical ecotheology in 2008, following the first ECOTHEE conference (ECOTHEE 08) held in Crete on the occasion of World Environment Day on June 5, 2008. Each ECOTHEE publication collects academic papers and statements by scientists, theologians, sociologists and researchers from different fields under the motto: “Religion and science can provide solutions to sustainability problems.” The articles selected in this seventh volume, ECOTHEE 22, continue the development of ecotheological resources on environmental ethics and sustainable solutions for the common oikos. This book follows the ECOTHEE goal and seeks to engage theology on key ecological concerns from a variety of religious traditions and perspectives. The emphasis is on theological and ethical implications of contributing to a sustainable ecological future. This publication is enriched with additional articles from the 5th SAPREJ conference on sustainable alternatives to poverty reduction and eco-justice and the roles, responsibilities and initiatives of religion, science and civil societies for ecological justice and biodiversity protection, held in Addis Ababa, Ethiopia, in May 2023. /// The present ECOTHEE 22 book is structured into the following sections: Introduction, Section 1: Towards Reconciliation and Justice for all Creation (Eco-ethical Theological and Philosophical Reflections), Section 2: Governance, Politics, Good Practices, and Critical Evaluations of Ecological (In)Justice. /// An “Anthology of Contemporary Ecotheology, Philosophy and Eco-Justice Practices” volume of ECOTHEE delivers chapters on contemporary insights into various religious, spiritual, philosophical reflections towards reconciliation and ecojustice for a sustainable future.
Objavljeno v DiRROS: 11.09.2024; Ogledov: 468; Prenosov: 1530
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Povzetek: Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot be studied in preclinical in vitro models. In this study, we investigated the effects of standard therapy using patient-derived GB organoids (GBOs). GBOs reflect the complexity and heterogeneity of the original tumor tissue. No significant effect on GBO viability or invasion was observed after irradiation and temozolomide treatment. E3 ubiquitin-protein ligase (MDM2), cyclin-dependent kinase inhibitor 1A (CDKN1A), and the serine/threonine kinases ATM and ATR were upregulated at the gene and protein levels after treatment. Our results show that the p53 pathway and DNA-damage response mechanisms were triggered, suggesting that GBOs recapitulate GB therapy resistance. GBOs thus provide a highly efficient platform to assess the specific responses of GB patients to therapy and to further explore therapy resistance.
Ključne besede: cellular physiology, cellular toxicology, in vitro toxicology including 3D culture, technical aspects of cell biology, cancer
Objavljeno v DiRROS: 09.09.2024; Ogledov: 360; Prenosov: 168
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Objavljeno v DiRROS: 09.09.2024; Ogledov: 321; Prenosov: 4006
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Povzetek: Wood is considered a promising raw material for the circular bioeconomy and has the ability to store biogenic carbon, and this is one reason why we want to extend the service life of the wood. In order to consider the influence of durability in our study, we used two wood species with different lifespans. Beech (Fagus sylvatica L.) belongs to the group of very sensitive wood species, as the durability of the untreated wood is estimated to be around 5 years; meanwhile, pine (Pinus sylvestris L.) belongs to the group of moderately resistant wood species, where the durability of the untreated wood is estimated to be up to 15 years. While toxic chemicals are often used for wood preservation, hydroxyapatite offers an environmentally friendly solution for wood mineralization. This study presents life cycle assessment (LCA) and life cycle cost (LCC) analyses comparing a novel hydroxyapatite (HAp) mineralization method with a service life of 50 years to a non-mineralized reference alternative. LCA was based on EN ISO 14040 and EN ISO 14044, while LCC was adapted from the European Commission’s LCC tool for public procurement. The results of the LCA show that mineralized wood has a lower overall impact on the environment than surface-treated beech wood but a higher impact than surface-treated pine wood. Most impact categories were determined by electricity consumption with the exception of stratospheric ozone depletion, water consumption, and land use. Water consumption proved to be the category where the mineralization process was problematic due to water consumption during the leaching process. The LCC showed that mineralized wood is the most cost-effective solution for the exterior façade, as all costs, but especially investment costs, were lower. The differences in the LCA and LCC results are mainly due to the different lifetimes of the two alternatives. It can be concluded that if energy-intensive processes and chemicals are used in the production of the material, the extended lifetime must be sufficient to account for the additional impacts that occur during the production phase.
Ključne besede: environmental impacts, hydroxyapatite, life cycle assessment (LCA), life cycle cost analysis (LCC), wood mineralization
Objavljeno v DiRROS: 09.09.2024; Ogledov: 321; Prenosov: 2609
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Ključne besede: varstvo gozdov, morfološke analize
Objavljeno v DiRROS: 06.09.2024; Ogledov: 284; Prenosov: 0
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