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Povzetek: Background. Position sensitive silicon microstrip detectors are used as sensors for X rays in a digital imaging system. Silicon detectors were used inan edgeon geometry, yielding high X ray detection efficiency. Material and methods. A small detector system was assembled and tested. Images of a standard, 5 cm thick phantom were made and evaluated. It is demonstrated, thatthe use of silicon detectors in mammography could significantly contributeto a reduction of dose. All images were made with skin entrance doses lower than 1 mGy. Results and conclusion. Microcalcifications with a diameter of 350microm could still be detected with skin entrance doses of about 0.25 mGy. It was demonstrated that a 5 Ip/mm pattern can be detected. Image processing should further improve the image quality.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 331; Prenosov: 61
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Povzetek: Background. The aim of this work was to study the configuration of the microtubules in the cytochalasin B treated V-79 cells in connection to the cell shape and to see whether there are any similarities to the phenomena taking place in phospholipid vesicles. Subjects and methods. An experiment wasperformed where cytochalasin B was added to the V-79 cells (lung fibroblasts of Chinese hamster). Results. The cell shape changed from an elongated one into the shape with a profile resembling the Greek letter phi. The microtubules were found to be organized into a rod within the symmetry axis of the cell. Conclusion. As similar shapes were previously observed also in the phospholipid vesicles with entrapped microtubule rods, our results support the hypothesis that similar physical mechanisms may pertain in simple systems as well as in living cells.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 283; Prenosov: 48
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Povzetek: Background. The aim of the study was the evaluation of clinical utility and comparison of 111 In-DTPA- octreotide receptor scintigraphy (SRS) with conventional imaging modalities (CIM) in the detection of carcinoid tumor. Patients and methods. Fourteen patients with pathohistologically proven diagnosis of carcinoid tumor and one patient with clinical suspicion of carcinoid tumor were investigated by SRS. SRS was performed for localization of primary tumor, recurrence or estimation of spread of the disease after CIM had been completed. Whole body scans and single photon emission computed tomography (SPECT) were acquired 6 and 24 h after the application of radiopharmaceutical. The intensity of nonspecific radiopharmaceutical uptake in the bowel was assessed semiquantitatively by a score using whole body scans. Results. The evaluation was done for patients and for tumor sites. The sensitivity, specificity, and positive and negative predictive values for patient evaluation were 89 %,100 %,100 % and 80 %, respectively for both CIM and SRS, whereas for tumor sites, these parameters were 69 % 100 %,100 % and 82 % for CIM, and 88%,100%,100% and 92 % for SRS. Intensity score of nonspecific 111In-octreotide bowel accumulation was 0.92 and 2.01 for 6 and 24h scans respectively (p < 0.01). Conclusion. 111In-octreotide scintigraphy should be included in the diagnostic algorithm for the patients with clinical suspicion of carcinoid and for the assessment of patients with proven carcinoid tumor.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 222; Prenosov: 45
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Povzetek: Background. The aim of this study was to determine the interaction between electrochemotherapy as a means of facilitated cisplatin delivery into the cells and irradiation of adenocarcinoma skin metastases. Case report. A patient with progressive disease presenting skin metastases of tubal dedifferentiated pappilary adenocarcinoma was enrolled in the study. Skin metastases were treated by electrochemotherapy with intratumoral injection of cisplatin. Its antitumor effectiveness was compared to that of combined treatment of irradiation with electrochemotherapy. After a two week observation time, the response to treatment was comparable between the electrochemotherapy and electrochemotherapy combined with irradiation. Both ofthese treatments were more effective than irradiation alone. Furthermore, antitumor effectiveness of the combined electrochemo- and radiotherapy was found to be quicker than that of electrochemotherapy alone. Comment. This study shows that electrochemotherapy with cisplatin is also effective in the treatment of adenocarcinoma skin metastases. Inspite of the short observation time, positive interaction between radiotherapy and electrochemotherapy with cisplatin was found.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 221; Prenosov: 62
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Povzetek: Buckground. Endoanal ultrasound (EUS) is helpful in the diagnosis of anorectalfistulas and abscesses due to its high resolution image quality and anatomical orientation using a radial scanning echoprobe. This type of information is essential in monitoring the response to treatment. Initial EUS examination prior to treatment, is mandatory in order to compare the results before and after treatment. Intraoperative EUS may also be helpful if the lesion is deep beyond the pelvic floor muscle which may not be seen during surgery. Better results in EUS imaging of perianorectal fistulas can be obtained using hydrogen peroxide as a contrast medium. Concomitant advantage of hydrogen peroxide ultrasound was the detection of suspected or unsuspected sphincter defects. However, interobserver reliability has to be taken into account together with the learning curve of a particular observer. Conclusions. Endoanal US is a safe, economic, and reliable procedure for the assessment of fistula-in-ano, and is superior to physical examination.
Objavljeno v DiRROS: 22.01.2024; Ogledov: 221; Prenosov: 50
Celotno besedilo (401,37 KB)