1131. Surovinske potrebe za zagotavljanje prehoda na trajnostno in pametno mobilnost : zbornik povzetkov konferenčnih prispevkov2022, druge monografije in druga zaključena dela Povzetek: EIT Urbana mobilnost RIS Hub Slovenija, koordinirana s strani Zavoda za gradbeništvo Slovenije, deluje kot nacionalna kontaktna točka za skupnost urbana mobilnost, ki deluje pod okriljem Evropskega inštituta za inovacije in tehnologijo. Osredotočenost na izboljševanje življenjskih razmer v mestih, spodbujanje inovacij na področju zelenih in varnih rešitev za mobilnost ljudi, blaga in odpadkov, pospeševanje tržnih priložnosti v avtomobilski industriji ter oblikovanje zakonodajnega okvira za spremembe so le nekateri strateški cilji skupnosti KIC EIT Urbana mobilnost. Z namenom spodbujanja povezovanja, združevanja in povečevanja partnerstva med obema sektorjema (surovine in mobilnost), neposredno vpletenima v prehod na bolj trajnostne oblike mobilnosti, je bila 24. oktobra 2022 organizirana spletna konferenca EIT OPEN DAY SLOVENIJA2022 – Surovinske potrebe za zagotavljanje prehoda na trajnostno in pametno mobilnost. Konferenca je bila organizirana s strani Zavoda za gradbeništvo Slovenije, v sodelovanju z Regionalnim centrom Adria EIT Surovine RIS Hub in Javno agencijo SPIRIT Slovenija. Dogodek je bil razdeljen v štiri segmente, v okviru katerih je obravnaval finančne spodbude in mehanizme za zagotavljanje trajnostnega prehoda, tudi z uporabo novih in inovativnih lahkih zlitin ter vodikovih in baterijsko-električnih tehnologij.
Ključne besede: urbana mobilnost, pametna mobilnost, trajnostna mobilnost, mesta, trajnostni razvoj, urbano okolje, surovine, lahke zlitine, vodikove tehnologije, baterijsko električne tehnologije
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1132. Current trends in diagnostic nuclear medicine instrumentationValentin Fidler, 2000, pregledni znanstveni članek Povzetek: Introduction. The basic principles of nuclear medicine imaging instruments aredescribed with the emphasis on multi crystal scintillation and semiconductor gamma cameras, positron emission scanners without detector inter-ring attenuation septa, new detector materials and semiconductor CZT surgical probes for localization of metastases. For the estimation of minimal useful detector diameter the theoretical equation was derived for the 20% lossof absorbed gamma rays at the edge of the detector. Conclusion. Nuclear medicine instrumentation has been passing throgh vigorous development in the last years and will be most likely also in the near future. New detection materials with much better physical characteristics than the standard NaI as regards the stopping power, energy resolutions, fragility, decay time, light output, and density will most likely replace the NaI. It is expected that new imaging devices with several thousands of tiny crystals or semiconductor arrayof small position sensitive areas will improve the sensitivity and specificity of clinical studies. At the same time the small surgical probes made from these materials are also becoming very popular in surgery tracing the regional metastases.
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1133. The relationship between DNA methylation and expression of three different DNA methyltransferases in ovarian cancerAndrej Cör, 2000, izvirni znanstveni članek Povzetek: Background. DNA methylation in mammals is required for embryonic development, X chromosome inactivation and imprinting. Previous studies have shown that methylation patterns become abnormal in malignant cells and may contribute to tumorigenesis. The aim of the study was to ascertain the relationship between overall DNA methylation and the expression of DNMT1, DNMT3A and DNMT3B in ovarian cancer samples. Material and methods. DNA digestion with either methylation sensitive HpaII, or methylation insensitive MspI restriction endonuclease and quantitative reverse transcription-PCR methods were used to analyse global methylation levels and expression levels of five ovarian cancerand three normal ovarian tissue samples. Results. All five analysed cancer samples were hypomethylated. The differences of methylation levels between normal ovarian tissue and carcinoma samples were statistically significant (P<0.05). All five cancer samples showed overexpression of DNMT3A and DNMT3B, and only two ovarian tumour samples showed overexpression of DNMT1. There was no correlation between global demethylation and expression levels for the three different DNMTs.Conclusion. Genome wide hypomethylation facilitates tumor development with predisposition of cells to structural and numerical chromosomal aberrations but the paradox of the global hypomethylation observed in cancer cells and the high levels of DNMTs that arepresent in these cells still remain to be resolved.
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1134. Electrochemotherapy with cisplatin of breast cancer tumor modules in a male patientMartina Reberšek, Tanja Čufer, Zvonimir Rudolf, Gregor Serša, 2000, izvirni znanstveni članek Povzetek: Background. The metastases of breast cancer in a male patient were treated with electrochemotherapy by intratumoral injection of cisplatin. Electrochemotherapy is chemotherapy with the subsequent local application of electric pulses to the tumor nodules in order to increase drug delivery into the cells. Case report. Cutaneous metastases of breast cancer were treated with the intratumoral administration of cisplatin and by 8 electric pulses (1300 V/cm) applied a minute later to each cutaneous metastasis. The treatmentresulted in complete response of two electrochemotherapy treated cutaneous metastases and partial response of the third metastasis. In cutaneous metastases treated with intratumoral administartion of cisplatin without electric pulses, only partial response was obtained. Conclusion. This study confirms that electrochemotherapy with cisplatin is effective in the treatment of breast cancer metastases, too, as it was already proved for electrochemotherapy with bleomycin.
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1135. Antibodies to p53 - can they serve as tumor markers in patients with malignantlymphomas?Barbara Jezeršek Novaković, Srdjan Novaković, 2000, izvirni znanstveni članek Povzetek: Background. Tumor suppressor gene p53 is mutated in approximately 21% of patients with nonHodgkin's lymphomas (the percentage varying from 0 up to 67% depending upon the histological type). Most of the mutations are point missense mutations resulting in nuclear accumulation of altered protein. Roughly one third of patients with overexpression of p53 protein develop circulating anti p53 antibodies. The present study was aimed at defining the usefulness of serial serological determinations of autoantibodies to p53 for clinical follow up of NHL patients. Patients and methods. Serum levels of antibodies to p53 were determined in various time intervals in three lymphoma patients (who had elevated serum levels at the time of diagnosis) for maximum two years using the commercially available ELISA kit p53-Autoantikoerper ELISA2. Generation. Results. In all three cases the temporal patterns of anti p53 antibodies reflected accurately disease progression or regression, and even foretold a relapse ten months in advance. The reflection of disease regression by autoantibodies lagged approximately three months behind the morphological disappearance of the disease due to a long half life of the antibodies. Conclusion. Our results confirmed the usefulness of antibodies to p53 as tumor markers for follow up of lymphoma patients, yet the subset of patients that could be appropriately followed up with this method is very limited due to the low proportion of patients that develop immune response to p53 protein.
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1136. Factors influencing rehabilitation in patients with head and neck cancerIrena Hočevar-Boltežar, Alojz Šmid, Miha Žargi, Avgust Župevc, Igor Fajdiga, Janez Fischinger, Ana Jarc, 2000, izvirni znanstveni članek Povzetek: Purpose. The purpose of the prospective study was to identify the factors adversely influencing the post-treatment rehabilitation in patients with head and neck cancer. Patients and methods. One hundred and ten patients with oral cavity, pharyngeal and laryngeal cancer were examined before surgical treatment in order to find unfavorable factors: hearing loss, defective teeth,impaired pulmonary function, and speech disorders. The patients evaluated the success of their rehabilitation 12 months after the treatment. The influence of possible unfavorable factors, tumor site, and type of surgeryon speech, swallowing and reintegration competence was determinated. Results. The site of the tumor and the type of surgery did not influence the quality of rehabilitation in general. Defective teeth influenced the ability of swallowing but not the speech. Hearing loss impaired the patient's reintegration in their home environment. Impaired pulmonary function did not affect patient's speech. Speech was the poorest in laryngectomized patients. However, about two thirds of the patients were satisfied with their capabilityof speech, swallowing and their rehabilitation in general. Conclusions. Early identification of unfavorable factors, and individually planned rehabilitation can ensure a suitable quality of life for patients thathave undergone surgery for head and neck cancer.
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1137. Do we need axillary dissection in early breast cancer?Tanja Čufer, 2000, objavljeni znanstveni prispevek na konferenci Povzetek: Background. In the existing paradigm of the invasive breast cancer, the treatment with the axillary lymphnode dissection (ALND) and histologic stagingof the axilla, which is associated with a substantial morbidity, is considered necessary for the treatment decision and local control of disease. However paradigms are changing and, since primary tumor characteristics are increasingly used for treatment decision and since there is a trend towards the broad application of preoperative chemotherapy, ALND is less and less important for the treatment planning. In a small subgroup of patients in whom the information on nodal status is still important it can be obtained accurately by the sentinel lymph node biopsy. For good local control of the disease, ALND can be replaced with irradiation of the axilla with substantially lesser morbidity. Conclusions. Abandoning ALND together with breast conserving surgery is one of the major steps towards less mutilating surgery leading to a better quality of life of breast cancer patients at the end of this millennium.
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