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1862. A critical appraisal of the use and properties of nickel–titanium dental alloysPetra Močnik, Tadeja Kosec, 2021, pregledni znanstveni članek Povzetek: Nickel–titanium (NiTi) archwires are used in dentistry for orthodontic treatment. NiTi alloys have favourable mechanical characteristics, such as superelasticity and shape memory, and are also known as a corrosion-resistant alloy. In specific cases, an archwire could be attacked by certain types of corrosion or wear degradation, which can cause the leaching of metal ions and a hypersensitive response due to increased concentrations of Ni in the human body. A systematic search of the literature retrieved 102 relevant studies. The review paper focuses on three main fields: (i) electrochemical properties of NiTi wires and the effect of different environments on the properties of NiTi wires (fluoride and low pH); (ii) tribocorrosion, a combination of chemical and mechanical wear of the material, and (iii) the biocompatibility of NiTi alloy and its subsequent effect on the human body. The review showed that corrosion properties are affected by microstructure, pH of saliva and the presence of fluorides. A high variation in published results should be, therefore, interpreted with care. The release of nickel ions was assessed using the same unit, showing that the vast majority of metal ions were released in the first few days of exposure, then a stable, steady state was reached. In tribocorrosion studies, the increased concentrations of Ni ions were reported. Ključne besede: NiTi alloy, archwires, corrosion, NI ion release Objavljeno v DiRROS: 23.02.2024; Ogledov: 505; Prenosov: 246
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1863. Real-time monitoring and analyses of sensory data integrated into the bim platformStanislav Lenart, Veljko Janjić, Uros Jovanovic, Rok Vezočnik, 2021, objavljeni znanstveni prispevek na konferenci Povzetek: Bridges and tunnels, crucial elements of the railway infrastructure, are exposed to various types of deterioration processes. Their condition is a subject of monitoring, as it is important to collect as much as possible information in every life cycle phase to reliably predict their future performance. An enormous quantity of monitoring data is generated during the whole life cycle of these assets. EU funded Shift2Rail research project Assets4Rail which is focusing on measuring, monitoring, and data handling for railway assets, as data management is as important as their generation. This paper presents the major outcomes of the Assets4Rail project and its application to infrastructure projects. Ključne besede: monitoring, information management, BIM, information management, bridge, tunnel, Assets4Rail Objavljeno v DiRROS: 23.02.2024; Ogledov: 441; Prenosov: 341
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1864. Cardiac tamponade as the initial manifestation of pulmonary adenocarcinoma : prikaz primera in pregled literatureMitja Letonja, Andrej Debeljak, 2007, strokovni članek Povzetek: Background. Neoplastic pericarditis can be presented as acute pericarditis, pericardial effusion, effusive-constrictive pericarditis or cardiac tamponade.For the majority of patients, a clinical manifestation of neoplasticpericarditis is absent or remains unrecognised during their life. Case report. A 69-year-old non-smoking woman with acute dyspnoea, tachycardia,jugular venous distension, hepatomegaly and right side pleural effusion was presented in the emergency department. The roentgen picture of the chest confirmed pleural effusion and revealed enlarged heart. An emergencyechocardiogram established the diagnosis of cardiac tamponade. The patient improved immediately after the therapeutic pericardiocentesis. Cytology of pericardial fluid confirmed malignant glandular cells, consistent with metastatic adenocarcinoma. A computed chest tomography showed a right side pleural effusion and a solitary round lesion in the right lower lobe of the lung. Bronchoscopy with fundoscopic lung biopsy and brushing revealed adenocarcinoma. Conclusions. Cardiac tamponade as the initial manifestation ofmalignancy is rare and rare is also malignant pericardial effusion due the adenocarcinoma of the lung in a non-smoking woman. The presented patient had one of the longest survival reported in literature despite a limited life expectancy regardless of the treatment in the patient presented with neoplastic pericarditis. Objavljeno v DiRROS: 22.02.2024; Ogledov: 429; Prenosov: 79
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1865. Quality of life following thoracotomy for lung cancerLučka Debevec, Irma Rozman Sinur, 2007, izvirni znanstveni članek Povzetek: Background. The aim of the study was to assess the preoperative and postoperative quality of life (QoL) in lung cancer patients undergoing thoracotomy and to compare the impairment of QoL in resected and exploratory thoracotomized (ET) patients. Patients and methods. Forty-three patients age 31 to 82 (mean 61) thoracotomized (lobectomy 29, bilobectomy 1, pneumonectomy 8, ET 5) for non-small cell lung cancer were assessed using the EORTC QLQ-LC30and QLQ-LC13 questionnaire preoperatively and a mean of 45 17 days after the thoracotomy and before eventual chemotherapy and radiation therapy. Results. After thoracotomy there were significantly impaired functional scales(physical functioning, role functioning, social functioning) and symptomscales (fatigue, constipation, appetite loss, dyspnoea, pain). The remaining symptoms (nausea/vomiting, insomnia, diarrhoea, coughing), global health status, functional scales (emotional functioning, cognitive functioning) and financial difficulties were impaired non-significantly. However, haemoptysis significantly improved and completely disappeared after thoracotomy. There were no significant differences between resected and ET patients. Conclusions. The study established significant impairment of QoL in the first two months after thoracotomy, but no significant differences betweenresected and ET patients. Objavljeno v DiRROS: 22.02.2024; Ogledov: 956; Prenosov: 126
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1866. Adjuvant treatment of breast cancer patients with trastuzumabErika Matos, Tanja Čufer, 2007, pregledni znanstveni članek Povzetek: Background. Trastuzumab is a monoclone antibody directed against HER2 receptors that are overexpressed in approximately 20% of breast cancer patients. The present paper presents five clinical trials in which trastuzumabwas applied in breast cancer patients in adjuvant setting. The results of all the trials consistently demonstrate a high efficacy of this target drug in the patients with HER2 positive tumours. So far, no formal guidelines for using trastuzumab in adjuvant setting for breast cancer have been approved. The reasons are many: (i) mean observation time in the studies done so far was considerably short; (ii) the drug was used according to different schedules, (iii) the overall time of treatment with trastuzumab was different in each trial, (iv) late side effects of treatment with trastuzumab are inadequately investigated, and (v) nobody can so far say for sure for which HER2 status patients therapy with trastuzumab is really beneficial. Conclusions. Trastuzumab is definitely very helpful in the treatment of the HER2-positive breast cancer patients that are hormone-independent and of anatomically larger tumours; but, what the absolute benefit of trastuzumab therapy in the treatment of small hormone-dependent tumours is remains a mystery. Incidentally, it must be borne in mind that cardiotoxicity, the well known side effect, may put particularly elderly patients at risk of death, thus beating any treatment advantages down. It has also not been yet resolved at what time it would be most appropriate to start with the therapy with trastuzumab, what would be the optimal duration of the therapy and whether trastuzumab is to be administered concurrently with chemotherapy or immediately after it? What is the optimal treatment duration, one or two yearsor only a few months? In addition there is still a question of optimal HER2 status determination and which HER2 status predicts for trastuzumab benefit. (Abstract truncated at 2000 characters) Objavljeno v DiRROS: 22.02.2024; Ogledov: 450; Prenosov: 101
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1868. CT-guided percutaneous transthoracic needle biopsy of lung lesions - 2-year experience at the Institute of radiology in LjubljanaIgor Kocijančič, Ksenija Kocijančič, 2007, izvirni znanstveni članek Povzetek: Background. In 1883, Leyden described percutaneous lung biopsy, but it was notuntil 1970s that image guided fine needle chest biopsy gained widespread acceptance. Haaga and Alfidi reported CT-guided thoracic biopsy in 1976. Currently, tissue sampling of a thoracic lesion is indicated when the diagnosis is not obtained by the endobronchial technique and when the cytological diagnosis will modify the stage of the disease or influence the therapeutic strategy. Cytology obtained by small-gauge needle aspiration biopsy confirms the nature of the lesion in 80 - 95% of cases and carry a low incidence of major complications according to the literature. The purpose of this retrospective analysis was to provide basic data about diagnostic accuracy and incidence of pneumothorax and chest tube insertion with respect to percutaneous transthoracic CT-guided needle biopsy of lung lesions. Methods. After positioning of the patient we performed a spiral CT of the thorax with the accordingly placed metal mark, which helped us to set the optimal cutaneous entry point. After that we re-checked the localisation of the lesion and marked the entry point with a pen and clean the surface to keepit sterile. After we applied local anaesthetic subcutaneously, we used coaxial 18G Gallini aspiration biopsy needles with cutting tip for CT- guided aspiration cytologic examination. The length of the needle was chosen according to the distance of the targeted lesion. Results. From January 2005 to January 2007 forty-three patients - 24 men and 19 women who were 26-79 years old (mean +/- SD, 59.8 +/- 10 years) were referred to the Institute of Radiology to undergo the PTNB. One patient was referred twice. Consequently, the hospital records and images of 44 consecutive cases of percutaneous transthoracic fine needle aspiration biopsy procedure were retrospectively analysed. (Abstract truncated at 2000 characters) Objavljeno v DiRROS: 22.02.2024; Ogledov: 427; Prenosov: 112
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1869. Adenocarcinoma of the small bowelMetka Šavli, Breda Jamar, 2007, strokovni članek Povzetek: Background. Adenocarcinoma of small bowel is generally a rather rare primary tumour of small bowel with a prevalence rate of 0.5-3.0/100.000 population, but the most frequent tumour of small intestine. It more often involves the duodenum and jejunum than the ileum. The aim of this paper is also to point out the value of small bowel follow through (SBFT) in the diagnosis of stenosing lesions. Case report. An 83-year old male patient suffered from abdominal pain, malaise, vomiting cachexia and diarrhoea for 3 months. The result of occult blood testing was negative. Haemoglobin level was normal. Proctoscopy, colonoscopy, upper gastrointestinal (GI) endoscopy, and ultrasonography (US) did not explain the patient's problems. Ileus of the small bowel was established with abdominal plain film. Small bowel follow through (SBFT) and computer tomography (CT) showed a stenosing tumour in the jejunum. Adenoearcinoma of the small bowel was established with histological examination after resection of the tumor. Conclusions. SBFT, with manual compression of all segments of the small bowel, can be a very accurate diagnostic investigation for evaluation of stenosing lesions in this part of the intestine. Objavljeno v DiRROS: 22.02.2024; Ogledov: 443; Prenosov: 73
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1870. Triple synchronous cancers : a medical and ethical problemLučka Debevec, Rok Cesar, Izidor Kern, 2007, izvirni znanstveni članek Povzetek: Background. In a patient with suspicious synchronous multiple tumours, there are limited possibilities for effective therapy. Therefore, the decision for invasive diagnostics and precise staging of tumours is questionable, especially in elderly patients suitable only for symptomatic therapy. Case report. A 78-year-old man with hypertension and angina pectoris was admitted to the hospital due to syncope. Two primary lung tumours and a kidney tumour were detected by imaging investigation. The patient refused invasive diagnostics and left the hospital. After 19 months he was readmitted in an impaired clinical condition and subsequently died of bronchopneumonia. The autopsy revealed squamous cell carcinoma of the right upper lobe with metastases to regional lymph nodes and to the brain, small-cell carcinoma of the left upper lobe with metastases to regional lymph nodes and to the spleen,and clear-cell kidney carcinoma with multiple metastases to the lungs. All tumours were necrotizing, and therefore we assumed that any attempt at specific therapy would have been ineffective. Conclusions. In an elderly patient with advanced lung tumors and suspicious synchronous triple cancers, the "wait and see" option can be suitable. Objavljeno v DiRROS: 22.02.2024; Ogledov: 407; Prenosov: 82
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