501. The process and procedures for the preparation of integrated maritime spatial planning : the case of SloveniaBarbara Goličnik Marušić, Andrej Gulič, 2025, izvirni znanstveni članek Povzetek: This article explores the establishment of a maritime spatial planning (MSP) framework in Slovenia. Following revised spatial planning legislation and the Directive 2014/89/EU, Slovenia initiated the development of processes and procedures for integrated MSP. Drawing on a dedicated research project, the article presents a proposed methodology grounded in the ecosystem approach, forming a foundation for integrated land–sea interaction planning. The framework outlines a four‐phase process: (1) preliminary MSPlan preparation, (2) MSPlan preparation, (3) MSPlan monitoring and evaluation of implementation, and (4) ongoing MSPlan monitoring and updating. Each phase consists of independent or sequential steps, which are also linked procedurally between the phases. A central feature linking the preliminary and main preparation phases is stakeholder involvement. While the MSPlan preparation phase ensures broad stakeholder participation, the preliminary phase engages those representing strategic development or conservation interests. Experts and other stakeholder groups may also be involved directly in the planning process. The article concludes by evaluating the adopted Slovenian MSPlan, highlighting deviations from the proposed process and assessing the extent of its implementation in relation to the original plan. It also emphasises the importance of developing the MSP process and its procedures in parallel to ensure strong alignment and facilitate a smoother preparation of the final MSPlan.
Ključne besede: coastal governance, research, maritime spatial planning, North Adriatic Sea
Objavljeno v DiRROS: 20.11.2025; Ogledov: 130; Prenosov: 47
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503. Mapping temperature, humidity, air quality, and noise-related comfort conditions to identify urban planning issues : a case of study of Ljubljana, SloveniaŽiva Ravnikar, Alfonso Bahillo, Barbara Goličnik Marušić, 2025, izvirni znanstveni članek Ključne besede: public space, research, urban planning
Objavljeno v DiRROS: 20.11.2025; Ogledov: 158; Prenosov: 31
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504. Climate change reflected in 40-year isotopic composition trends of precipitation in SloveniaJan Gačnik, Klara Žagar, István Gábor Hatvani, Zoltán Kern, Polona Vreča, 2026, izvirni znanstveni članek Povzetek: Long-term monitoring of stable isotopes in precipitation (δ18O, δ2 H), alongside meteorological data, is key to understanding how large-scale hydroclimate variability influences regional and local climate. This study presents one of the longest records in Central and Southeastern Europe: the multi-decadal (1981–2024) dataset of monthly composite precipitation stable isotope records from Ljubljana, Slovenia. The δ18O, δ2 H, and d-excess values are increasing (+0.02 ‰, +0.18 ‰, and +0.05 ‰ per year, respectively), consistent with regional warming. Seasonal patterns were evident, with elevated d-excess values during autumn. The decomposition of the δ18O, δ2 H and d-excess time series using Hilbert-Huang Transform revealed statistically significant annual oscillations in all variables. These oscillations correlated strongly with the annual oscillation of temperature, but a lag of 2–3 months was identified for d-excess. Lower-frequency (multi-year) oscillations of d-excess were also observed. HYSPLIT back-trajectory analysis confirmed a significant contribution of Mediterranean-sourced air masses to autumn precipitation, but did not explain d-excess oscillations. Similar results were observed also for coastal (Portoroˇz, Slovenia) and continental (Vienna, Austria) stations. The findings imply an accelerating, exponential-like isotopic response to warming that has already propagated into the water cycle, providing isotope evidence that precipitation-surface water-groundwater interactions in investigated region changed in last decade.
Ključne besede: precipitation stable isotopes, trend analysis, Hilbert-Huang transform, ensemble empirical mode decomposition, HYSPLIT
Objavljeno v DiRROS: 19.11.2025; Ogledov: 130; Prenosov: 55
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505. Analysis of informed consent forms of patients undergoing cancer genetic testing in the era of next-generation sequencingTina Kerševan, Tina Kogovšek, Ana Blatnik, Mateja Krajc, 2025, izvirni znanstveni članek Povzetek: The Department of Clinical Cancer Genetics at the Institute of Oncology Ljubljana offers genetic counselling and testing to cancer patients and their relatives. Before undergoing genetic testing, patients sign the informed consent form. In addition to giving consent for collection of biological material and genetic testing, patients decide about storage of biological material and participation in international databases. Furthermore, patients decide whether the information regarding their test results may be revealed to their blood relatives and whether they want to be informed about secondary findings. Methods Using the signed consent forms, we investigated the effect of selected factors on patients’ decisions. Using different statistical methods, we tried to determine the proportion of patients who opted for different items and the effect of gender, age and cancer diagnoses on their decisions. Results Nearly all (99.6%) patients, regardless of gender, age, and presence of oncological diagnosis, consented to the storage of their biological material, 98.4% of patients, regardless of gender, age, and presence of oncological diagnosis, wanted to be included in international databases in a pseudo-anonymised form, 98.8% of patients, irrespective of gender, age, and presence of oncological diagnosis, allowed blood relatives to see their results, and 98.4% of patients, irrespective of gender, age and presence of oncological diagnosis, wanted to know whether secondary findings were detected when genetic analysis of their biological material was performed. Men are, on average, more likely to consent but the difference between genders is not statistically significant. Patients without oncological disease were more likely to agree to be included in international databases than patients with a confirmed oncological diagnosis. Conclusions Our results show that the vast majority of patients were in favour of the options they were offered. Most importantly, the majority of them allow their genetic test results be revealed to their blood relatives when needed and would participate in international databases. Research in rare diseases, including rare cancer genetic predisposition syndromes, is crucial for optimal diagnostic, prevention and treatment options for patients with rare genetic disorders. The results are also important for refining the approach to pre-and post-test cancer genetic counselling.
Ključne besede: informed consent, genetic counselling, genetic testing
Objavljeno v DiRROS: 19.11.2025; Ogledov: 118; Prenosov: 53
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506. Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccinationKatja Uršič Valentinuzzi, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Tilen Komel, Simon Buček, Maja Čemažar, Gregor Serša, 2025, izvirni znanstveni članek Povzetek: Introduction: In addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, we comprehensively analyzed this dual effectiveness of intratumoral ECT with chemotherapeutic drugs bleomycin (BLM), oxaliplatin (OXA), and cisplatin (CDDP). Our aim was to determine if ECT can act as in situ vaccination and thereby induce an abscopal effect. By evaluating ECT’s potential for in situ vaccination, our goal was to pave the way for future advancements for its combination with emerging (immuno)therapies, leading to enhanced responses and outcomes. Methods: We employed two mouse tumor models, the immunologically cold B16F10 melanoma and 4T1 mammary carcinoma, to explore both local and systemic (i.e., abscopal) antitumor effects following equieffective intratumoral ECT with BLM, OXA, and CDDP. Through histological analyses and the use of immunodeficient and metastatic (for abscopal effect) mouse models, we identified and compared both the cytotoxic and immunological components of ECT’s antitumor efficiency, such as immunologically recognizable cell deaths (immunogenic cell death and necrosis) and immune infiltrate (CD11+, CD4+, CD8+, GrB+). Results: Differences in immunological involvement after equieffective intratumoral ECT were highlighted by variable kinetics of immunologically recognizable cell deaths and immune infiltrate across the studied tumor models. Particularly, the 4T1 tumor model exhibited a more pronounced involvement of the immune component compared to the B16F10 tumor model. Variances in the antitumor (immune) response were also detected based on the chemotherapeutic drug used in ECT. Collectively, ECT demonstrated effectiveness in inducing in situ vaccination in both tumor models; however, an abscopal effect was observed in the 4T1 tumor model only. Conclusions: This is the first preclinical study systematically comparing the immune involvement in intratumoral ECT’s efficiency using three distinct chemotherapeutic drugs in mouse tumor models. The demonstrated variability in immune response to ECT across different tumor models and chemotherapeutic drugs provides a basis for future investigations aimed at enhancing the effectiveness of combined treatments.
Ključne besede: electroporation, chemotherapeutic drugs, mouse tumor models
Objavljeno v DiRROS: 19.11.2025; Ogledov: 176; Prenosov: 81
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