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Povzetek: Background. Sclerosing melanocytic lesions, which are characterized by either focal or diffuse sclerosis in the dermal component and atypical proliferation of predominantly nevoid melanocytes, remain poorly defined. Our aim was to analyze systematically their morphologic spectrum, especially the distinction between sclerosing melanocytic nevus and sclerosing melanoma, which has not been well documented. Patients and methods. We collected 90 sclerosing melanocytic lesions, occurring in 82 patients (49 male, 33 female; age range from 21 to 89 years). A four probe fluorescent in situ hybridization (FISH) assay was performed in 41 lesions to substantiate the diagnosis of sclerosing melanomas. Results. A prominent full-thickness pagetoid spread of melanocytes was identified in 44 (48%) lesions, and a melanoma in situ adjacent to the sclerosis in 55 (61%) lesions. In the intrasclerotic component, maturation was absent in 40 (44%) and mitotic figures were identified in 18 (20%) lesions. Of the 90 lesions, 26 (29%) were diagnosed morphologically as nevi and 64 (71%) as melanomas (Breslow thickness from 0.4 to 1.8 mm), including 45 (50%) melanomas with an adjacent nevus. A four-probe FISH assay was positive in the sclerotic component in 14 of 25 lesions diagnosed morphologically as melanomas and none of 16 nevi. A sentinel lymph node biopsy was performed for 17 lesions and was negative in all cases. Conclusions. Sclerosing melanocytic lesions form a morphologic spectrum and include both nevi and melanomas. The pathogenesis of sclerosis remains obscure but seems to be induced by melanocytes or an unusual host response in at least a subset of lesions.
Ključne besede: sclerosing melanoma, sclerosing nevus, fibrosis
Objavljeno v DiRROS: 02.07.2024; Ogledov: 395; Prenosov: 249
Celotno besedilo (1,34 MB)

Ključne besede: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija
Objavljeno v DiRROS: 02.07.2024; Ogledov: 454; Prenosov: 208
Celotno besedilo (5,88 MB)

Ključne besede: vegetacija, tla, rastišča, ekologija gozdov, Javna gozdarska služba, Slovenija
Objavljeno v DiRROS: 02.07.2024; Ogledov: 421; Prenosov: 184
Celotno besedilo (5,87 MB)

Povzetek: The basic idea was to create a proof of concept demonstrating that the indoor navigation and localisation is possible using only passive tags. For this purpose, a smartphone navigation app was developed to be used in inner parts of the buildings and which can operate with no satellite positioning service available and no communication network present. The satellite navigation systems (GPS, GLONASS, Galileo, BeiDou, QZSS, IRNSS) inside buildings, at least on lower floors and cellars, in central parts, and away from windows, usually do not work, or their accuracy is very reduced due to a small number of visible satellites. The communication networks (WiFi, LTE, 5G…) might not be available in some circumstances such as catastrophic incidents, power reductions, or similar, which disables the localisation systems based on them. The purpose of the smartphone app was twofold. First, to develop a reliable, simple-to-use, and cheap indoor navigation system that could be used in large buildings like hospitals, shopping malls, trade centres, fairs, etc. where no other positioning service is available. Second, to develop an indoor position reporting system that can be used in accidents and mass-casualty incidents for reporting triage decisions to the server. Both functionalities are based on the QR codes [1] holding all the information needed.
Ključne besede: internet thinks, indoor navigation, systems, QR codes
Objavljeno v DiRROS: 02.07.2024; Ogledov: 366; Prenosov: 214
Celotno besedilo (931,78 KB)
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Ključne besede: konfigurator, plastični rezervoarji, polimerni materiali, tehnološki procesi, konstrukcija rezervoarjev, diplomsko delo
Objavljeno v DiRROS: 01.07.2024; Ogledov: 433; Prenosov: 181
Celotno besedilo (3,61 MB)