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Naslov:Proteases and cytokines as mediators of interactions between cancer and stromal cells in tumours
Avtorji:ID Breznik, Barbara (Avtor)
ID Motaln, Helena (Avtor)
ID Lah Turnšek, Tamara (Avtor)
Datoteke:.pdf PDF - Predstavitvena datoteka, prenos (951,87 KB)
MD5: E4B68029A7F38DC6BBEFADE113F85876
PID: 20.500.12556/dirros/4cce7bee-2d6d-4b94-bde2-8b38a35bc385
 
Jezik:Angleški jezik
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:Logo NIB - Nacionalni inštitut za biologijo
Povzetek:Proteolytic enzymes are highly relevant in different processes of cancer progression. Their interplay with other signalling molecules such as cytokines represents important regulation of multicellular cross-talk. In this review, we discuss protease regulation mechanisms of cytokine signalling in various types of cancer. Additionally, we highlight the reverse whereby cytokines have an impact on protease expression in an autocrine and paracrine manner, representing complex feedback mechanisms among multiple members of these two protein families. The relevance of the protease-cytokine axis is illustrated in glioblastoma, where interactions between normal mesenchymal stem cells and cancer cells play an important role in this very malignant form of brain cancer.
Ključne besede:cellular cross-talk, glioblastoma, invasion, mesenchymal stem cells, protease-cytokine signalling
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Založnik:De Gruyter
Št. strani:str. 709-719
Številčenje:Vol. 398, No. 7
PID:20.500.12556/DiRROS-8095 Novo okno
Datum objave v DiRROS:08.09.2017
Število ogledov:3115
Število prenosov:1005
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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