| Naslov: | Detecting subtle cognitive impairment in patients with Parkinson’s disease and normal cognition : a novel cognitive control challenge task (C3T) |
|---|
| Avtorji: | ID Resnik Robida, Karmen (Avtor)
ID Politakis, Vida Ana (Avtor)
ID Oblak, Aleš (Avtor)
ID Slana Ozimič, Anka (Avtor)
ID Burger, Helena (Avtor)
ID Pirtošek, Zvezdan (Avtor)
ID Bon, Jurij (Avtor) |
|---|
| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,51 MB)
MD5: D5075971D70E0F277FA3424CC799A5A2
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2076-3425/13/6/961
|
|---|
| Jezik: | Angleški jezik |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
|
|---|
| Povzetek: | Patients with Parkinson’s disease (PD) often show early deficits in cognitive control, with primary difficulties in flexibility and relatively intact stable representations. The aim of our study was to assess executive function using an ecologically valid approach that combines measures of stability and flexibility. Fourteen patients without cognitive deficits and sixteen comparable control subjects completed a standardized neuropsychological test battery and a newly developed cognitive control challenge task (C3T). We found that the accuracy of C3T performance decreased with age in healthy participants and remained impaired in PD patients regardless of age. In addition, PD patients showed significantly lower overall performance for cognitive control tasks than healthy controls, even when they scored in the normal range on standardized neuropsychological tests. PD Patients responded significantly faster than healthy control subjects regarding flexible cognitive control tasks due to their impulsivity. Correlations showed that the C3T task targets multiple cognitive systems, including working memory, inhibition, and task switching, providing a reliable measure of complex cognitive control. C3T could be a valuable tool for characterizing cognitive deficits associated with PD and appears to be a more sensitive measure than standardized neuropsychological tests. A different assessment approach could potentially detect early signs of the disease and identify opportunities for early intervention with neuroprotective therapies. |
|---|
| Ključne besede: | stable cognitive control, flexible cognitive control, cognitive control challenge task, Parkinson’s disease, task switching |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Leto izida: | 2023 |
|---|
| Št. strani: | str. 1-18 |
|---|
| Številčenje: | Vol. 13, iss. 6 |
|---|
| PID: | 20.500.12556/DiRROS-31627  |
|---|
| UDK: | 616.8 |
|---|
| ISSN pri članku: | 2076-3425 |
|---|
| DOI: | 10.3390/brainsci13060961 |
|---|
| COBISS.SI-ID: | 156747267 |
|---|
| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 26. 6. 2023;
|
|---|
| Datum objave v DiRROS: | 05.08.2026 |
|---|
| Število ogledov: | 143 |
|---|
| Število prenosov: | 84 |
|---|
| Metapodatki: |    |
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
