| Naslov: | Genetic polymorphisms in oxidative stress and inflammatory pathways as potential biomarkers in Alzheimer’s Disease and dementia |
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| Avtorji: | ID Vogrinc, David (Avtor)
ID Gregorič Kramberger, Milica (Avtor)
ID Emeršič, Andreja (Avtor)
ID Čučnik, Saša (Avtor)
ID Goričar, Katja (Avtor)
ID Dolžan, Vita (Avtor) |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (1,14 MB)
MD5: 27B8B65E7A24F2962EF31EE0A3C35F52
 URL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2076-3921/12/2/316
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Oxidative stress and neuroinflammation are important processes involved in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Numerous risk factors, including genetic background, can affect the complex interplay between those mechanisms in the aging brain and can also affect typical AD hallmarks: amyloid plaques and neurofibrillary tangles. Our aim was to evaluate the association of polymorphisms in oxidative stress- and inflammation-related genes with cerebrospinal fluid (CSF) biomarker levels and cognitive test results. The study included 54 AD patients, 14 MCI patients with pathological CSF biomarker levels, 20 MCI patients with normal CSF biomarker levels and 62 controls. Carriers of two polymorphic IL1B rs16944 alleles had higher CSF Aβ1–42 levels (p = 0.025), while carriers of at least one polymorphic NFE2L2 rs35652124 allele had lower CSF Aβ1–42 levels (p = 0.040). Association with IL1B rs16944 remained significant in the AD group (p = 0.029). Additionally, MIR146A rs2910164 was associated with Aβ42/40 ratio (p = 0.043) in AD. Significant associations with cognitive test scores were observed for CAT rs1001179 (p = 0.022), GSTP1 rs1138272 (p = 0.005), KEAP1 rs1048290 and rs9676881 (both p = 0.019), as well as NFE2L2 rs35652124 (p = 0.030). In the AD group, IL1B rs1071676 (p = 0.004), KEAP1 rs1048290 and rs9676881 (both p = 0.035) remained associated with cognitive scores. Polymorphisms in antioxidative and inflammation genes might be associated with CSF biomarkers and cognitive test scores and could serve as additional biomarkers contributing to early diagnosis of dementia. |
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| Ključne besede: | Alzheimer’s disease, oxidative stress, inflammation |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2023 |
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| Št. strani: | str. 1-20 |
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| Številčenje: | Vol. 12, iss. 2 |
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| PID: | 20.500.12556/DiRROS-31483  |
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| UDK: | 616.8 |
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| ISSN pri članku: | 2076-3921 |
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| DOI: | 10.3390/antiox12020316 |
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| COBISS.SI-ID: | 139886083 |
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| Opomba: |
Nasl. z nasl. zaslona;
Opis z dne 30. 1. 2023;
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| Datum objave v DiRROS: | 03.08.2026 |
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| Število ogledov: | 234 |
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| Število prenosov: | 105 |
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| Metapodatki: |    |
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