| Naslov: | Stoma-free survival after rectal cancer resection with anastomotic leakage : development and validation of a prediction model in a large international cohort |
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| Avtorji: | ID Greijdanus, Nynke G. (Avtor)
ID Wienholts, Kiedo (Avtor)
ID Ubels, Sander (Avtor)
ID Talboom, Kevin (Avtor)
ID Hannink, Gerjon (Avtor)
ID Wolthuis, Albert (Avtor)
ID de Lacy, Francisco B (Avtor)
ID Lefevre, Jérémie H (Avtor)
ID Solomon, Michael (Avtor)
ID Frasson, Matteo (Avtor)
ID Grosek, Jan (Sodelavec pri raziskavi)
ID Košir, Jurij Aleš (Sodelavec pri raziskavi)
ID Tomažič, Aleš (Sodelavec pri raziskavi)
ID Košir Božič, Tajda (Sodelavec pri raziskavi), et al. |
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| Datoteke: |  PDF - Predstavitvena datoteka, prenos (311,48 KB)
MD5: 60758B4949EE8A0B26D6F8745AF9C879
 URL - Izvorni URL, za dostop obiščite https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549897/pdf/sla-278-00772.pdf
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  UKC LJ - Univerzitetni klinični center Ljubljana
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| Povzetek: | Objective: To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL). Background: AL after RC resection often results in a permanent stoma. Methods: This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated. Results: This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76). Conclusions: The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies. |
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| Ključne besede: | anastomotic leakage, rectal cancer, rectal cancer resection, stoma-free survival permanent |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Leto izida: | 2023 |
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| Št. strani: | str. 772-780 |
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| Številčenje: | Vol. 278, iss. 5 |
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| PID: | 20.500.12556/DiRROS-31479  |
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| UDK: | 61 |
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| ISSN pri članku: | 1528-1140 |
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| DOI: | 10.1097/SLA.0000000000006043 |
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| COBISS.SI-ID: | 161810947 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 18. 8. 2023;
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| Datum objave v DiRROS: | 03.08.2026 |
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| Število ogledov: | 66 |
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| Število prenosov: | 37 |
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| Metapodatki: |    |
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