| Naslov: | Immunophenotyping, activation, and expansion of gamma delta T cells: flow cytometry profiling and ex vivo manipulation strategies |
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| Avtorji: | ID Rupar, Urška (Avtor)
ID Bertoncelj, Pia (Avtor)
ID Leben Zupet, Katja (Avtor)
ID Markelj, Gašper (Avtor)
ID Vesel, Tina (Avtor)
ID Šamec, Neja (Avtor)
ID Avčin, Tadej (Avtor)
ID Pohar, Jelka (Avtor)
ID Smole, Anže (Avtor) |
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| Datoteke: |  URL - Izvorni URL, za dostop obiščite https://doi.org/10.3389/fimmu.2026.1829178
 PDF - Predstavitvena datoteka, prenos (1,57 MB)
MD5: F7137F15E2B0BF36EE3AC68022E16906
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| Jezik: | Angleški jezik |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: |  NIB - Nacionalni inštitut za biologijo
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| Povzetek: | Gamma delta (γδ) T cells exhibit unique antiviral, antibacterial, and antitumor properties. Advancing the fundamental understanding of γδ T cell immunobiology and unlocking their full therapeutic potential requires detailed immunophenotypic profiling alongside optimized strategies for ex vivo activation and expansion. In this review, we synthesize current knowledge of γδ T cell immunobiology, emphasizing (i) comprehensive phenotypic characterization using flow cytometry and (ii) emerging approaches for their therapeutic implementation, with a focus on activation and ex vivo expansion methods. By integrating insights from phenotypic analysis with a comparative evaluation of expansion techniques, we provide an overview of γδ T cell immunobiology and their translational potential in immunotherapy. |
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| Ključne besede: | barrier immunity, cellular immunotherapy, flow cytometry, gamma delta (γδ) T cells, immune dysregulation, immunophenotyping, γδ T cell activation, γδ T cell expansion, immunology |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Datum objave: | 31.07.2026 |
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| Leto izida: | 2026 |
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| Št. strani: | 1-14 str. |
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| Številčenje: | Vol. 17 |
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| PID: | 20.500.12556/DiRROS-31461  |
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| UDK: | 616-097 |
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| ISSN pri članku: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1829178 |
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| COBISS.SI-ID: | 286715651 |
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| Opomba: | Nasl. z nasl. zaslona;
Opis vira z dne 3. 8. 2026;
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| Datum objave v DiRROS: | 03.08.2026 |
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| Število ogledov: | 31 |
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| Število prenosov: | 21 |
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| Metapodatki: |    |
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